Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme100013 cd27 sp1

ECD Proteins

Human CD27 Protein, mFc-His Tag

SKU:  PME100013     Target:  CD27

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100012 b7 h3 sp1

ECD Proteins

Human B7-H3 Protein, mFc-His Tag

SKU:  PME100012     Target:  B7-H3

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100010 2b4 sp1

ECD Proteins

Human 2B4 Protein, mFc-His Tag

SKU:  PME100010     Target:  2B4

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100036 s rbd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S protein RBD, His Tag

SKU:  PME100036     Target:  S protein RBD

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100072 ace2 sp1

ECD Proteins

Human ACE2 Protein, mFc Tag

SKU:  PME100072     Target:  ACE2

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100667 gfap sp1

ECD Proteins

Human GFAP (68-377) Protein, His Tag

SKU:  PME100667     Target:  GFAP

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100657 nucleocapsid sp1

ECD Proteins

SARS-CoV-2 (Delta) Nucleocapsid, C-His Tag

SKU:  PME100657     Target:  Nucleocapsid

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100670 cd166 sp1

ECD Proteins

Human CD166 Protein, His Tag

SKU:  PME100670     Target:  CD166

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100671 rspo3 sp1

ECD Proteins

Human RSPO3 (22-146) Protein, hFc Tag

SKU:  PME100671     Target:  RSPO3

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100655 folr2 sp1

ECD Proteins

Human FOLR2 Protein, His Tag

SKU:  PME100655     Target:  FOLR2

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100μg ￥4299.00

sp-pme100649 kras sp1

ECD Proteins

Human KRAS Protein, His Tag

SKU:  PME100649     Target:  KRAS

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100648 nefl sp1

ECD Proteins

Human NEFL (89-400) Protein, His Tag

SKU:  PME100648     Target:  NEFL

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100647 s protein rbd sp1

ECD Proteins

SARS-CoV-2 (Delta) S protein RBD, His Tag

SKU:  PME100647     Target:  S protein RBD

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100008 cd47 sp1

ECD Proteins

Human CD47 Protein, mFc-His Tag

SKU:  PME100008     Target:  CD47

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100007 flt3 sp1

ECD Proteins

Human FLT3 Protein, hFc-His Tag

SKU:  PME100007     Target:  FLT3

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100006 cd138 sp1

ECD Proteins

Human CD138 Protein, hFc-His Tag

SKU:  PME100006     Target:  CD138

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100005 cd22 sp1

ECD Proteins

Human CD22 Protein, hFc-His Tag

SKU:  PME100005     Target:  CD22

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100004 cd38 sp1

ECD Proteins

Human CD38 Protein, hFc-His Tag

SKU:  PME100004     Target:  CD38

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100003 cd123 sp1

ECD Proteins

Human CD123 Protein, hFc-His Tag

SKU:  PME100003     Target:  CD123

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100002 cs1 sp1

ECD Proteins

Human CS1 Protein, hFc-His Tag

SKU:  PME100002     Target:  CS1

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100001 bcma sp1

ECD Proteins

Human BCMA Protein, hFc-His Tag

SKU:  PME100001     Target:  BCMA

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-PME100296 IL17RB His PAGE 72

ECD Proteins

Human IL17RB Protein, His Tag

SKU:  PME100296     Target:  IL17RB

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-PME100849 CD9 Fig.1 SDS PAGE 1

ECD Proteins

Human CD9 Protein, His Tag

SKU:  PME100849     Target:  CD9

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-PME100609 CLEC1A hFc PAGE 72

ECD Proteins

Human CLEC1A Protein, hFc Tag

SKU:  PME100609     Target:  CLEC1A

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-PME100530 CD38 Fig.1 SDS PAGE 1

ECD Proteins

Human CD38 Protein, hFc Tag

SKU:  PME100530     Target:  CD38

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

sp-PME100533 AXL mFc PAGE 72

ECD Proteins

Human AXL Protein, mFc Tag

SKU:  PME100533     Target:  AXL

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-PME101102 CD32a R167 hFc PAGE 300 1

ECD Proteins

Human CD32a (R167) Protein, hFc Tag

SKU:  PME101102     Target:  CD32a

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme101099 scgb2a2 sp1

ECD Proteins

Human SCGB2A2 Protein, hFc Tag

SKU:  PME101099     Target:  SCGB2A2

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-PME101098 ADAM17 Fig.1 SDS PAGE 1

ECD Proteins

Human ADAM17(581-642) Protein, hFc Tag

SKU:  PME101098     Target:  ADAM17

Price: 10μg ￥600.00 ; 50μg ￥2199.00 ; 100μg ￥3299.00

sp-PME100967 ITGB5 Fig.1 SDS PAGE 1

ECD Proteins

Human ITGB5 Protein, hFc Tag

SKU:  PME100967     Target:  ITGB5

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100μg ￥3499.00

sp-PME100935 CXCL12 Fig.1 SDS PAGE 1

ECD Proteins

Human CXCL12 Protein, hFc Tag

SKU:  PME100935     Target:  CXCL12

Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00

sp-pme100859 cd1a sp1

ECD Proteins

Human CD1A Protein, hFc Tag

SKU:  PME100859     Target:  CD1A

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00