对于单次穿膜蛋白来说，DIMA可提供功能活性和高稳定性的胞外区重组蛋白（ECD蛋白）。这些蛋白经过广泛测试和验证，以确保其功能完整性，使它们非常适用于药物研究和开发的各种应用场景。
High Purity, High Bioactivity
High Purity, High Bioactivity
Protein Purity
Figure 1. Human SIRPa, hFc-His Tag (A) and CD47, mFc-His Tag (B) on SDS-PAGE under reducing condition.
Receptor-ligand interaction
Figure 2. Human CD47 protein (PME100008) can bind its native ligand Human SIRPα protein (PME100009) in a linear range of 3.3-26.37 ng/ml.
Biosimilar interaction
Figure 3. Human CD47 protein (PME100008) can bind Anti-CD47 mAb (BME100001) in a linear range of 0.061-1.606 ng/ml.
Freeze-thaw stability testing
Protein Purity
Lane 1: Human SIRPα protein without freeze-thaw treatment; Lane 2: Human SIRPα protein after one freeze-thaw cycle; Lane 3: Human SIRPα protein after three freeze-thaw cycles; Lane 4: Human SIRPα protein after five freeze-thaw cycles.
Receptor-ligand interaction
A: Human SIRPα without freeze-thaw treatment; B: Human SIRPα protein after one freeze-thaw cycle; C: Human SIRPα protein after three freeze-thaw cycles; D: Human SIRPα protein after five freeze-thaw cycles.
Storage Stability: Shelf Life Testing
ACE2-hFc, 37℃, 1, 2, 3 days storage stability
Lane 1: Human ACE2 protein after storage at -20℃; Lane 2: Human ACE2 protein after storage at 37℃ after 24h; Lane 3: Human ACE2 protein after storage at 37℃ after 48h; Lane 4: Human ACE2 protein after storage at 37℃ after 72h.
S-RBD protein (PME100497) can bind Human ACE2 protein ( PME100073) (Stored at -20℃ or 37℃ for 24h, 48h and 72h) in a linear range of 0.488-49.83 ng/ml.
CCR8-hFc, 37℃, 1, 2, 3 days storage stability
Lane 1: Human CCR8 protein (PME101091) after storage at -20℃; Lane 2: Human CCR8 protein after storage at 37℃ after 24h; Lane 3: Human CCR8 protein after storage at 37℃ after 48h; Lane 4: Human CCR8 protein after storage at 37℃ after 72h.
Human CCR8 protein (PME101091) ( (Stored at -20℃ or 37℃ for 24h, 48h and 72h) ) can bind Anti-CCR8 Neutralizing antibody (BME100063) in a linear range of 3.2-80 ng/ml.
Storage Stability Testing After Reconstitution
37℃, 1, 2, 3 days storage stability after reconstitution of lyophilized protein
PME100073: Human ACE2 Protein, hFc Tag
PME101091: Human CCR8 Protein, hFc
Lot-to-lot consistency
CCR8-hFc lot-to-lot consistency
Different batches of Human CCR8 Protein (PME101091) can bind Anti-CCR8 Neutralizi) on SDS-PAGE under reducing condition.
Different batches Human CCR8 protein (PME101091) can bind Anti-CCR8 Neutralizing antibody (BME100063) in a linear range of 3.2-80 ng/ml.
