Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme100465 tnfrsf10b sp1

ECD Proteins

Human TNFRSF10B Protein, mFc Tag

SKU:  PME100465     Target:  TNFRSF10B

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100067 csf1r sp1

ECD Proteins

Human CSF1R Protein, His Tag

SKU:  PME100067     Target:  CSF1R

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100048 btla sp1

ECD Proteins

Human BTLA Protein, mFc-His Tag

SKU:  PME100048     Target:  BTLA

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100068 epcam sp1

ECD Proteins

Human EPCAM Protein, His Tag

SKU:  PME100068     Target:  EPCAM

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100050 dnam 1 sp1

ECD Proteins

Human DNAM-1 Protein, mFc-His Tag

SKU:  PME100050     Target:  DNAM1

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100045 epha3 sp1

ECD Proteins

Human EPHA3 Protein, mFc-His Tag

SKU:  PME100045     Target:  EPHA3

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100464 cd7 sp1

ECD Proteins

Human CD7 Protein, mFc Tag

SKU:  PME100464     Target:  CD7

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100463 tweakr sp1

ECD Proteins

Human TweakR Protein, mFc Tag

SKU:  PME100463     Target:  TweakR

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100462 pd1 sp1

ECD Proteins

Human PD-1 Protein, hFc-His tag

SKU:  PME100462     Target:  PD-1

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100461 pd 1 sp1

ECD Proteins

Human PD-1 Protein, His tag

SKU:  PME100461     Target:  PD-1

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100460 s rbd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S protein RBD, mFc-His Tag

SKU:  PME100460     Target:  S protein RBD

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100459 nucleocapsid sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) Nucleocapsid, N-His Tag

SKU:  PME100459     Target:  Nucleocapsid

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100034 b7 2 sp1

ECD Proteins

Human B7-2 Protein, mFc-His Tag

SKU:  PME100034     Target:  B7-2

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100033 flt3lg sp1

ECD Proteins

Human FLT3 Ligand Protein, mFc-His Tag

SKU:  PME100033     Target:  FLT3LG

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100032 il6 sp1

ECD Proteins

Human IL6 Protein, mFc-His Tag

SKU:  PME100032     Target:  IL6

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100031 msln296 sp1

ECD Proteins

Human Mesothelin (296-580) Protein, mFc-His Tag

SKU:  PME100031     Target:  Mesothelin

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100030 tim3 sp1

ECD Proteins

Human TIM3 Protein, mFc-His Tag

SKU:  PME100030     Target:  TIM3

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100029 b7 h2 sp1

ECD Proteins

Human B7-H2 Protein, mFc-His Tag

SKU:  PME100029     Target:  B7-H2

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100028 cd96 sp1

ECD Proteins

Human CD96 Protein, mFc-His tag

SKU:  PME100028     Target:  CD96

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100027 cd155 sp1

ECD Proteins

Human CD155 Protein, mFc-His tag

SKU:  PME100027     Target:  CD155

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100026 icos sp1

ECD Proteins

Human ICOS Protein, mFc-His tag

SKU:  PME100026     Target:  ICOS

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100024 slamf1 sp1

ECD Proteins

Human SLAMF1 Protein, mFc-His tag

SKU:  PME100024     Target:  SLAMF1

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100023 pdl1 sp1

ECD Proteins

Human PD-L1 Protein, mFc-His tag

SKU:  PME100023     Target:  PDL1

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100022 ox40 sp1

ECD Proteins

Human OX40 Protein, hFc-His tag

SKU:  PME100022     Target:  OX40

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100021 ox40l sp1

ECD Proteins

Human OX40L Protein, mFc-His tag

SKU:  PME100021     Target:  OX40 Ligand

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100025 pd1 sp1

ECD Proteins

Human PD-1 Protein, mFc-His tag

SKU:  PME100025     Target:  PD-1

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100011 4 1bb sp1

ECD Proteins

Human 4-1BB Protein, mFc-His Tag

SKU:  PME100011     Target:  4-1BB

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100020 gitr ligand sp1

ECD Proteins

Human GITR Ligand Protein, mFc-His tag

SKU:  PME100020     Target:  GITR Ligand

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100019 gitr sp1

ECD Proteins

Human GITR Protein, mFc-His tag

SKU:  PME100019     Target:  GITR

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100016 cd48 sp1

ECD Proteins

Human CD48 Protein, mFc-His Tag

SKU:  PME100016     Target:  CD48

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100015 cd40 sp1

ECD Proteins

Human CD40 Protein, mFc-His Tag

SKU:  PME100015     Target:  CD40

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100014 cd28 sp1

ECD Proteins

Human CD28 Protein, mFc-His Tag

SKU:  PME100014     Target:  CD28

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00