Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme100038 cd19 sp1

ECD Proteins

Human CD19 Protein, hFc-His tag

SKU:  PME100038     Target:  CD19

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100506 tigit sp1

ECD Proteins

Human TIGIT Protein, His Tag

SKU:  PME100506     Target:  TIGIT

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100505 tigit sp1

ECD Proteins

Human TIGIT Protein, mFc Tag

SKU:  PME100505     Target:  TIGIT

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100107 tigit sp1

ECD Proteins

Human TIGIT Protein, hFc Tag

SKU:  PME100107     Target:  TIGIT

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100054 4 1bb ligand sp1

ECD Proteins

Human 4-1BB Ligand Protein, mFc-His Tag

SKU:  PME100054     Target:  4-1BB Ligand

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme m100035 stab1 sp1

ECD Proteins

Mouse STAB1 Protein, hFc Tag

SKU:  PME-M100035     Target:  STAB1

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100041 cd30 ligand sp1

ECD Proteins

Human CD30 Ligand Protein, mFc-His Tag

SKU:  PME100041     Target:  CD30 Ligand

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100800 cd3d sp1

ECD Proteins

Human CD3D Protein, His Tag

SKU:  PME100800     Target:  CD3D

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100504 nucleocapsid sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) Nucleocapsid, C-His Tag

SKU:  PME100504     Target:  Nucleocapsid

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100092 siglec10 sp1

ECD Proteins

Human SIGLEC10 Protein, His Tag

SKU:  PME100092     Target:  SIGLEC10

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100091 cd37 sp1

ECD Proteins

Human CD37 Protein, hFc Tag

SKU:  PME100091     Target:  CD37

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100088 her3 sp1

ECD Proteins

Human HER3 Protein, His Tag

SKU:  PME100088     Target:  HER3

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100085 il5 sp1

ECD Proteins

Human IL5 Protein, His Tag

SKU:  PME100085     Target:  IL5

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100503 baff r sp1

ECD Proteins

Human BAFF-R Protein, hFc Tag

SKU:  PME100503     Target:  BAFF-R

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100471 cd162 sp1

ECD Proteins

Human CD162 Protein, His Tag

SKU:  PME100471     Target:  SELPLG

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100044 baff r sp1

ECD Proteins

Human BAFF-R Protein, mFc Tag

SKU:  PME100044     Target:  BAFF-R

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100043 baff sp1

ECD Proteins

Human BAFF Protein, hFc Tag

SKU:  PME100043     Target:  BAFF

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100502 4 1bb sp1

ECD Proteins

Human 4-1BB Protein, His tag

SKU:  PME100502     Target:  4-1BB

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100084 psca sp1

ECD Proteins

Human PSCA Protein, hFc Tag

SKU:  PME100084     Target:  PSCA

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100083 cd114 sp1

ECD Proteins

Human CD114 Protein, His Tag

SKU:  PME100083     Target:  CD114

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100081 nkp30 sp1

ECD Proteins

Human NKp30 Protein, hFc Tag

SKU:  PME100081     Target:  NKp30

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100079 nkg2d sp1

ECD Proteins

Human NKG2D Protein, mFc Tag

SKU:  PME100079     Target:  NKG2D

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100499 igg1 fc sp1

ECD Proteins

Human IgG1-Fc Protein

SKU:  PME100499     Target:  IgG1-Fc

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100501 trop2 sp1

ECD Proteins

Human Trop2 Protein, mFc-His Tag

SKU:  PME100501     Target:  Trop2

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100476 cd48 sp1

ECD Proteins

Human CD48 Protein, hFc Tag

SKU:  PME100476     Target:  CD48

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100093 il5ra sp1

ECD Proteins

Human IL5RA Protein, His Tag

SKU:  PME100093     Target:  IL5RA

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100056 btn3a1 sp1

ECD Proteins

Human BTN3A1 Protein, mFc-His Tag

SKU:  PME100056     Target:  BTN3A1

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100480 pd l1 sp1

ECD Proteins

Human PD-L1 Protein, His tag

SKU:  PME100480     Target:  PDL1

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100479 ctla 4 sp1

ECD Proteins

Human CTLA-4 Protein, hFc tag

SKU:  PME100479     Target:  CTLA-4

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100478 gitr ligand sp1

ECD Proteins

Human GITR Ligand Protein, His tag

SKU:  PME100478     Target:  GITR Ligand

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100475 cd27 sp1

ECD Proteins

Human CD27 Protein, hFc Tag

SKU:  PME100475     Target:  CD27

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100402 siglec15 sp1

ECD Proteins

Human SIGLEC15 Protein, mFc-His Tag

SKU:  PME100402     Target:  SIGLEC15

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00