Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme100087 selp sp1

ECD Proteins

Human SELP Protein, hFc Tag

SKU:  PME100087     Target:  SELP

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100062 icam 1 sp1

ECD Proteins

Human ICAM-1 Protein, mFc Tag

SKU:  PME100062     Target:  ICAM-1

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100058 slamf5 sp1

ECD Proteins

Human SLAMF5 Protein, mFc-His Tag

SKU:  PME100058     Target:  SLAMF5

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100487 s rbd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S protein RBD, hFc Tag

SKU:  PME100487     Target:  S protein RBD

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100498 rbd m sp1

ECD Proteins

SARS-CoV-2 Spike-Membrane Recombinant Fusion Protein, His Tag

SKU:  PME100498     Target:  S protein

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100497 rbd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S protein RBD, mFc Tag

SKU:  PME100497     Target:  S protein RBD

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100496 s1 protein ctd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S1 protein CTD, hFc Tag

SKU:  PME100496     Target:  S1 protein CTD

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100493 s1 protein ntd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S1 protein NTD, hFc Tag

SKU:  PME100493     Target:  S1 protein NTD

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100492 s1 protein ntd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S1 protein NTD, mFc Tag

SKU:  PME100492     Target:  S1 protein NTD

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100491 s1 protein ntd sp1

ECD Proteins

SARS-CoV-2 (2019-nCoV) S1 protein NTD, His Tag

SKU:  PME100491     Target:  S1 protein NTD

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100485 cd155 sp1

ECD Proteins

Human CD155 Protein, hFc tag

SKU:  PME100485     Target:  CD155

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100484 icos sp1

ECD Proteins

Human ICOS Protein, hFc tag

SKU:  PME100484     Target:  ICOS

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100486 cd70 sp1

ECD Proteins

Human CD70 Protein, hFc-His Tag

SKU:  PME100486     Target:  CD70

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme101103 ccr8 sp1

ECD Proteins

Human CCR8 Protein, mFc Tag

SKU:  PME101103     Target:  CCR8

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100474 b7 2 sp1

ECD Proteins

Human B7-2 Protein, hFc Tag

SKU:  PME100474     Target:  B7-2

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100473 b7 1 sp1

ECD Proteins

Human B7-1 Protein, hFc Tag

SKU:  PME100473     Target:  B7-1

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100477 2b4 sp1

ECD Proteins

Human 2B4 Protein, hFc tag

SKU:  PME100477     Target:  2B4

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100076 tnfa sp1

ECD Proteins

Human TNFa Protein, His Tag

SKU:  PME100076     Target:  TNFA

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100074 il2rb sp1

ECD Proteins

Human IL2RB Protein, His Tag

SKU:  PME100074     Target:  IL2RB

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100073 ace2 sp1

ECD Proteins

Human ACE2 Protein, hFc Tag

SKU:  PME100073     Target:  ACE2

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100071 cecam5 sp1

ECD Proteins

Human CEACAM5 Protein, His Tag

SKU:  PME100071     Target:  CEACAM5

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100035 bcma sp1

ECD Proteins

Human BCMA Protein, mFc Tag

SKU:  PME100035     Target:  BCMA

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100470 cd5 sp1

ECD Proteins

Human CD5 Protein, His Tag

SKU:  PME100470     Target:  CD5

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100466 cd200 sp1

ECD Proteins

Human CD200 Protein, His Tag

SKU:  PME100466     Target:  CD200

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100070 axl sp1

ECD Proteins

Human AXL Protein, His Tag

SKU:  PME100070     Target:  AXL

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100069 fcgr3a sp1

ECD Proteins

Human FCGR3A Protein (F176V), His Tag

SKU:  PME100069     Target:  FCGR3A

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100061 cd52 sp1

ECD Proteins

Human CD52 Protein, mFc Tag

SKU:  PME100061     Target:  CD52

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100042 cd70 sp1

ECD Proteins

Human CD70 Protein, mFc-His Tag

SKU:  PME100042     Target:  CD70

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-pme100039 cd33 sp1

ECD Proteins

Human CD33(18-259) Protein, hFc-His Tag

SKU:  PME100039     Target:  CD33

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100059 ntba sp1

ECD Proteins

Human NTB-A Protein, mFc-His Tag

SKU:  PME100059     Target:  NTB-A

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100469 cd34 sp1

ECD Proteins

Human CD34 Protein, His Tag

SKU:  PME100469     Target:  CD34

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100468 il17ra sp1

ECD Proteins

Human IL17RA Protein, His Tag

SKU:  PME100468     Target:  IL17RA

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00