Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

pages-416107bc534d939 1

DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

pages-cvsdvdfffffb 1

In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme48043 biglycan sp1

ECD Proteins

Human Biglycan (BGN) (NM_001711) Protein

SKU:  PME48043     Target:  Biglycan

Price: 50 μg ￥2720.00

sp-pme100125b acpp sp1

ECD Proteins

Biotinylated Human ACPP Protein, His Tag

SKU:  PME100125B     Target:  ACPP

Price: 10μg ￥740.00 ; 50μg ￥2700.00 ; 100 μg ￥4070.00

sp-pme100125 acpp sp1

ECD Proteins

Human ACPP Protein, His Tag

SKU:  PME100125     Target:  ACPP

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme c100089 cd19 sp1

ECD Proteins

Cynomolgus CD19 Protein, His Tag

SKU:  PME-C100089     Target:  CD19

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme m100126 il4ra sp1

ECD Proteins

Mouse IL4RA Protein, His Tag

SKU:  PME-M100126     Target:  IL4RA

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme c100092 c5ar1 sp1

ECD Proteins

Cynomolgus C5AR1 Protein, hFc Tag

SKU:  PME-C100092     Target:  C5AR1

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme c100091 gpr75 sp1

ECD Proteins

Cynomolgus GPR75 Protein, hFc Tag

SKU:  PME-C100091     Target:  GPR75

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme c100090 cd38 sp1

ECD Proteins

Cynomolgus CD38 Protein, His Tag

SKU:  PME-C100090     Target:  CD38

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

sp-pme101834 b7 h3 sp1

ECD Proteins

Human B7-H3(27-461) Protein, hFc Tag

SKU:  PME101834     Target:  B7-H3

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme101833 oprd1 sp1

ECD Proteins

Human OPRD1 Protein, hFc Tag

SKU:  PME101833     Target:  OPRD1

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101832 opn4 sp1

ECD Proteins

Human OPN4 Protein, hFc Tag

SKU:  PME101832     Target:  OPN4

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101831 b7 h3 sp1

ECD Proteins

Human B7-H3(29-245) Protein, hFc Tag

SKU:  PME101831     Target:  B7-H3

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme101830 cd8a sp1

ECD Proteins

Human CD8A Acidic tail Protein, His Tag

SKU:  PME101830     Target:  CD8A

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme101829 itga4 sp1

ECD Proteins

Human ITGA4(1-977) Acidic tail Protein, hFc Tag

SKU:  PME101829     Target:  ITGA4

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101828 avpr1a sp1

ECD Proteins

Human AVPR1A Protein, hFc Tag

SKU:  PME101828     Target:  AVPR1A

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101827 ackr2 sp1

ECD Proteins

Human ACKR2 Protein, hFc Tag

SKU:  PME101827     Target:  ACKR2

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101826 gpr37 sp1

ECD Proteins

Human GPR37 Protein, His Tag

SKU:  PME101826     Target:  GPR37

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101824 il22ra1 sp1

ECD Proteins

Human IL22RA1 Protein, hFc Tag

SKU:  PME101824     Target:  IL22RA1

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101823 npy2r sp1

ECD Proteins

Human NPY2R Protein, hFc Tag

SKU:  PME101823     Target:  NPY2R

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101822 npy1r sp1

ECD Proteins

Human NPY1R Protein, hFc Tag

SKU:  PME101822     Target:  NPY1R

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101821 kl sp1

ECD Proteins

Human KL Protein, His Tag

SKU:  PME101821     Target:  KL

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101820 igfbp3 sp1

ECD Proteins

Human IGFBP3 Protein, His Tag

SKU:  PME101820     Target:  IGFBP3

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101819 il27ra sp1

ECD Proteins

Human IL27RA(33-516) Protein, hFc Tag

SKU:  PME101819     Target:  IL27RA

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101818 olfml3 sp1

ECD Proteins

Human OLFML3 Protein, hFc Tag

SKU:  PME101818     Target:  OLFML3

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101817 dcn sp1

ECD Proteins

Human DCN(31-359) Protein, His Tag

SKU:  PME101817     Target:  DCN

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101816 dcn sp1

ECD Proteins

Human DCN(17-359) Protein, His Tag

SKU:  PME101816     Target:  DCN

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101815 vipr2 sp1

ECD Proteins

Human VIPR2 Protein, hFc Tag

SKU:  PME101815     Target:  VIPR2

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101814 vipr1 sp1

ECD Proteins

Human VIPR1 Protein, hFc Tag

SKU:  PME101814     Target:  VIPR1

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101813 tas2r38 sp1

ECD Proteins

Human TAS2R38 Protein, hFc Tag

SKU:  PME101813     Target:  TAS2R38

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101812 sstr3 sp1

ECD Proteins

Human SSTR3 Protein, hFc Tag

SKU:  PME101812     Target:  SSTR3

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101811 sstr1 sp1

ECD Proteins

Human SSTR1 Protein, hFc Tag

SKU:  PME101811     Target:  SSTR1

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00

sp-pme101810 sctr sp1

ECD Proteins

Human SCTR Protein, hFc Tag

SKU:  PME101810     Target:  SCTR

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100μg ￥3160.00