药物靶点重组兔单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

热门抗体靶点

2B44-1BB4-1BB-LSIRPα
B7-H3BCMACD123CD48
CD138CD22CD27GITR Ligand
CD28CD38CD47CS1
GPRC5DCTLA-4MSLNTROP2
GITRTIM3B7-2PSCA
NKp30BTN3A1DNAM1B7-H2
CD40

验证数据展示

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A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.

Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.

Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10µg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10µg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)

A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay. 

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Affinity ranking of different Rabbit anti-CS1 mAb clones (DM9, DM10, DM11) by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

antibody-dme101184b il19 elisa1

Monoclonal Antibodies

Biotinylated Anti-IL19 antibody(2A3), Rabbit mAb

SKU:  DME101184B     Target:  IL19

Application:  ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

antibody-dme101183b gpr56 elisa1

Monoclonal Antibodies

Biotinylated Anti-GPR56 antibody(2H4), Rabbit mAb

SKU:  DME101183B     Target:  GPR56

Application:  ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

antibody-dme101182b cxcl10 elisa1

Monoclonal Antibodies

Biotinylated Anti-CXCL10 antibody(2A5), Rabbit mAb

SKU:  DME101182B     Target:  CXCL10

Application:  ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

antibody-dmc101338p sez6 fc1

Monoclonal Antibodies

PE-Anti-SEZ6 antibody(15F4), IgG1 Chimeric mAb

SKU:  DMC101338P      Target:  SEZ6

Application:  Flow Cyt

Price: 100 test ￥3880.00

占位

Monoclonal Antibodies

Biotinylated Anti-SEZ6 antibody(15F4), IgG1 Chimeric mAb

SKU:  DMC101338B     Target:  SEZ6

Application:  Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

antibody-dmc101338 sez6 fc1

Monoclonal Antibodies

Anti-SEZ6 antibody(15F4), IgG1 Chimeric mAb

SKU:  DMC101338     Target:  SEZ6

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101301 meltf fc1

Monoclonal Antibodies

Anti-MELTF antibody(1D12), Rabbit mAb

SKU:  DME101301     Target:  MELTF

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101300 ibsp elisa1

Monoclonal Antibodies

Anti-IBSP antibody(3A11), Rabbit mAb

SKU:  DME101300     Target:  IBSP

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101299 adam15 fc1

Monoclonal Antibodies

Anti-ADAM15 antibody(1G8), Rabbit mAb

SKU:  DME101299     Target:  ADAM15

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101298 dlk1 fc1

Monoclonal Antibodies

Anti-DLK1 antibody(2C5), Rabbit mAb

SKU:  DME101298     Target:  DLK1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101297 btc fc1

Monoclonal Antibodies

Anti-BTC antibody(1F4), Rabbit mAb

SKU:  DME101297     Target:  BTC

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101296 mst1r fc1

Monoclonal Antibodies

Anti-MST1R antibody(1G10), Rabbit mAb

SKU:  DME101296     Target:  MST1R

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101295 nrp1 fc1

Monoclonal Antibodies

Anti-NRP1 antibody(1F11), Rabbit mAb

SKU:  DME101295     Target:  NRP1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101294 mc4r fc1

Monoclonal Antibodies

Anti-MC4R antibody(2H10), Rabbit mAb

SKU:  DME101294     Target:  MC4R

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101293 ecscr fc1

Monoclonal Antibodies

Anti-ECSCR antibody(1A7), Rabbit mAb

SKU:  DME101293     Target:  ECSCR

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101292 gpr20 fc1

Monoclonal Antibodies

Anti-GPR20 antibody(1E10), Rabbit mAb

SKU:  DME101292     Target:  GPR20

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101291 glp1r fc1

Monoclonal Antibodies

Anti-GLP1R antibody(1A4), Rabbit mAb

SKU:  DME101291     Target:  GLP1R

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101290 grpr fc1

Monoclonal Antibodies

Anti-GRPR antibody(3B12), Rabbit mAb

SKU:  DME101290     Target:  GRPR

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101289 lrp10 fc1

Monoclonal Antibodies

Anti-LRP10 antibody(3E12), Rabbit mAb

SKU:  DME101289     Target:  LRP10

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101288 aplp2 fc1

Monoclonal Antibodies

Anti-APLP2 antibody(1F12), Rabbit mAb

SKU:  DME101288     Target:  APLP2

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme911453 spata46 ihc3

Monoclonal Antibodies

Anti-SPATA46 OTI2A9；Mouse mAb

SKU:  DME911453     Target:  SPATA46

Application:  IHC, WB

Price: 100ul ￥1999

antibody-dmc101406 his elisa1

Monoclonal Antibodies

Anti His (1B9) Chimeric mAb，Gallus lgY

SKU:  DMC101406     Target:  His Tag

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101219 btn3a3 fc1

Monoclonal Antibodies

Anti-BTN3A3 antibody(3E7), Rabbit mAb

SKU:  DME101219     Target:  BTN3A3

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dmc101405 cd200r1 fc1

Monoclonal Antibodies

Anti-CD200R1 antibody(3H1), IgG1 Chimeric mAb

SKU:  DMC101405     Target:  CD200R1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101210 kir2dl1 fc1

Monoclonal Antibodies

Anti-KIR2DL1 antibody(4H3), Rabbit mAb

SKU:  DME101210     Target:  KIR2DL1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101209 s100a9 elisa1

Monoclonal Antibodies

Anti-S100A9 antibody(1E12), Rabbit mAb

SKU:  DME101209     Target:  S100A9

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101208 nlrp3 elisa1

Monoclonal Antibodies

Anti-NLRP3 antibody(1B11), Rabbit mAb

SKU:  DME101208     Target:  NLRP3

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101207 ceacam8 fc1

Monoclonal Antibodies

Anti-CEACAM8 antibody(1H10), Rabbit mAb

SKU:  DME101207     Target:  CEACAM8

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101206 cxcl5 elisa1

Monoclonal Antibodies

Anti-CXCL5 antibody(3C1), Rabbit mAb

SKU:  DME101206     Target:  CXCL5

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101205 calr elisa1

Monoclonal Antibodies

Anti-CALR antibody(1A8), Rabbit mAb

SKU:  DME101205     Target:  CALR

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101204 bcam fc1

Monoclonal Antibodies

Anti-BCAM antibody(5B1), Rabbit mAb

SKU:  DME101204     Target:  BCAM

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme101203 pf4v1 elisa1

Monoclonal Antibodies

Anti-PF4V1 antibody(3E7), Rabbit mAb

SKU:  DME101203     Target:  PF4V1

Application:  ELISA

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00