Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme100834 cxcr4 sp1

ECD Proteins

Human CXCR4 Protein, hFc Tag

SKU:  PME100834     Target:  CXCR4

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100833 cxcr3 sp1

ECD Proteins

Human CXCR3 Protein, hFc Tag

SKU:  PME100833     Target:  CXCR3

Price: 10μg ￥690.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme100832 clec2d sp1

ECD Proteins

Human CLEC2D Protein, hFc Tag

SKU:  PME100832     Target:  CLEC2D

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

sp-pme100831 ceacam1 sp1

ECD Proteins

Human CEACAM1 Protein,His Tag

SKU:  PME100831     Target:  CEACAM1

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100830 c5ar1 sp1

ECD Proteins

Human C5AR1 Protein, hFc Tag

SKU:  PME100830     Target:  C5AR1

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100829 cd73 sp1

ECD Proteins

Human CD73 Protein, hFc Tag

SKU:  PME100829     Target:  CD73

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100828 cd3e sp1

ECD Proteins

Human CD3E Protein, hFc Tag

SKU:  PME100828     Target:  CD3E

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100827 cd200r1 sp1

ECD Proteins

Human CD200R1 Protein, His Tag

SKU:  PME100827     Target:  CD200R1

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100826 ccr9 sp1

ECD Proteins

Human CCR9 Protein, hFc Tag

SKU:  PME100826     Target:  CCR9

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100825 ccr7 sp1

ECD Proteins

Human CCR7 Protein, hFc Tag

SKU:  PME100825     Target:  CCR7

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100824 ccr4 sp1

ECD Proteins

Human CCR4 (1-39) Protein, hFc Tag

SKU:  PME100824     Target:  CCR4

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100822 ceacam6 sp1

ECD Proteins

Human CEACAM6 Protein, His Tag

SKU:  PME100822     Target:  CEACAM6

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme100821 mst1r sp1

ECD Proteins

Human MST1R Protein, hFc Tag

SKU:  PME100821     Target:  MST1R

Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00

sp-pme100820 cxcr1 sp1

ECD Proteins

Human CXCR1 Protein, hFc Tag

SKU:  PME100820     Target:  CXCR1

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100818 cd39 sp1

ECD Proteins

Human CD39 Protein, hFc Tag

SKU:  PME100818     Target:  CD39

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100813 cd21 sp1

ECD Proteins

Human CD21 Protein, hFc Tag

SKU:  PME100813     Target:  CD21

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100812 cd147 sp1

ECD Proteins

Human CD147 Protein, hFc Tag

SKU:  PME100812     Target:  CD147

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100810 anpep sp1

ECD Proteins

Human ANPEP Protein, His Tag

SKU:  PME100810     Target:  ANPEP

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100809 il4ra sp1

ECD Proteins

Human IL4RA Protein, hFc Tag

SKU:  PME100809     Target:  IL4RA

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

products-pme

ECD Proteins

Human ITGAM Protein, hFc Tag

SKU:  PME100808     Target:  ITGAM

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme100803 gpa33 sp1

ECD Proteins

Human GPA33 Protein, hFc Tag

SKU:  PME100803     Target:  GPA33

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100802 cdh3 sp1

ECD Proteins

Human CDH3 Protein, His Tag

SKU:  PME100802     Target:  CDH3

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100801 cdh17 sp1

ECD Proteins

Human CDH17 Protein, His Tag

SKU:  PME100801     Target:  CDH17

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100192 cd40 ligand sp1

ECD Proteins

Human CD40 Ligand Protein, hFc Tag

SKU:  PME100192     Target:  CD40 Ligand

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100103 tgfbr1 sp1

ECD Proteins

Human TGFBR1 Protein, N-hFc Tag

SKU:  PME100103     Target:  TGFBR1

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100102 cd46 sp1

ECD Proteins

Human CD46 Protein, His Tag

SKU:  PME100102     Target:  CD46

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100099 egfr sp1

ECD Proteins

Human EGFR Protein, His Tag

SKU:  PME100099     Target:  EGFR

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100098 il2ra sp1

ECD Proteins

Human IL2RA Protein, His Tag

SKU:  PME100098     Target:  IL2RA

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100097 ror2 sp1

ECD Proteins

Human ROR2 Protein, His Tag

SKU:  PME100097     Target:  ROR2

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100096 clec12a sp1

ECD Proteins

Human CLEC12A Protein, His Tag

SKU:  PME100096     Target:  CLEC12A

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100095 her2 sp1

ECD Proteins

Human Her2 Protein, His Tag

SKU:  PME100095     Target:  Her2

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-pme100094 taci sp1

ECD Proteins

Human TACI Protein, hFc Tag

SKU:  PME100094     Target:  TACI

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00