Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme100886 il1ra sp1

ECD Proteins

Human IL1RA Protein, hFc Tag

SKU:  PME100886     Target:  IL1RA

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100885 il17b sp1

ECD Proteins

Human IL17B Protein, hFc Tag

SKU:  PME100885     Target:  IL17B

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100884 il17a sp1

ECD Proteins

Human IL17A Protein, hFc Tag

SKU:  PME100884     Target:  IL17A

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100μg ￥4299.00

sp-pme100555 il21 sp1

ECD Proteins

Human IL21 Protein, mFc Tag

SKU:  PME100555     Target:  IL21

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100882 il15 sp1

ECD Proteins

Human IL15 Protein, hFc Tag

SKU:  PME100882     Target:  IL15

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100881 il12rb1 sp1

ECD Proteins

Human IL12RB1 Protein, His Tag

SKU:  PME100881     Target:  IL12RB1

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100879 il10r sp1

ECD Proteins

Human IL10R Protein, hFc Tag

SKU:  PME100879     Target:  IL10R

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100878 il10 sp1

ECD Proteins

Human IL10 Protein, hFc Tag

SKU:  PME100878     Target:  IL10

Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00

sp-pme100588 c mpl sp1

ECD Proteins

Human c-MPL Protein, hFc Tag

SKU:  PME100588     Target:  c-MPL

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100872 il13 sp1

ECD Proteins

Human IL13 Protein, hFc Tag

SKU:  PME100872     Target:  IL13

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100871 gnrhr sp1

ECD Proteins

Human GNRHR Protein, hFc Tag

SKU:  PME100871     Target:  GNRHR

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100870 gdnf sp1

ECD Proteins

Human GDNF Protein, hFc Tag

SKU:  PME100870     Target:  GDNF

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100868 folr2 sp1

ECD Proteins

Human FOLR2 Protein, hFc Tag

SKU:  PME100868     Target:  FOLR2

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100μg ￥4299.00

sp-pme100867 fcmr sp1

ECD Proteins

Human FCMR Protein, hFc Tag

SKU:  PME100867     Target:  FCMR

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme100863 colec10 sp1

ECD Proteins

Human COLEC10 Protein, hFc Tag

SKU:  PME100863     Target:  COLEC10

Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00

sp-pme100862 cldn3 sp1

ECD Proteins

Human CLDN3 Protein, hFc Tag

SKU:  PME100862     Target:  CLDN3

Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00

sp-pme100861 itgav itgb1 sp1

ECD Proteins

Human ITGAV and ITGB1 Heterodimer Protein, His Tag and hFc Tag

SKU:  PME100861     Target:  ITGAV and ITGB1

Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00

sp-pme100857 prom1 sp1

ECD Proteins

Human PROM1 Protein, hFc Tag

SKU:  PME100857     Target:  PROM1

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100156 cb2 sp1

ECD Proteins

Human CB2 (1-33) Protein, hFc Tag

SKU:  PME100156     Target:  CB2

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100855 vsig4 sp1

ECD Proteins

Human VSIG4 Protein, hFc Tag

SKU:  PME100855     Target:  VSIG4

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

sp-pme100853 tnfrsf11a sp1

ECD Proteins

Human TNFRSF11A Protein, hFc Tag

SKU:  PME100853     Target:  TNFRSF11A

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100852 ncr1 sp1

ECD Proteins

Human NCR1 Protein, hFc Tag

SKU:  PME100852     Target:  NCR1

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100623 chi3l1 sp1

ECD Proteins

Human CHI3L1 Protein, His Tag

SKU:  PME100623     Target:  CHI3L1

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100604 clu sp1

ECD Proteins

Human CLU Protein, His Tag

SKU:  PME100604     Target:  CLU

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100848 cd99 sp1

ECD Proteins

Human CD99 Protein, hFc Tag

SKU:  PME100848     Target:  CD99

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00

sp-pme100321 klrg1 sp1

ECD Proteins

Human KLRG1 Protein, hFc Tag

SKU:  PME100321     Target:  KLRG1

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

sp-pme100844 kir2dl2 sp1

ECD Proteins

Human KIR2DL2 Protein, hFc Tag

SKU:  PME100844     Target:  KIR2DL2

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00

sp-pme100841 il8 sp1 1

ECD Proteins

Human IL8 Protein, hFc Tag

SKU:  PME100841     Target:  IL8

Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00

sp-pme100840 il7ra sp1

ECD Proteins

Human IL7RA Protein, hFc Tag

SKU:  PME100840     Target:  IL7RA

Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100μg ￥3999.00

sp-pme100838 il1b sp1

ECD Proteins

Human IL1B Protein, hFc Tag

SKU:  PME100838     Target:  IL1B

Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00

sp-pme100836 lrrc32 sp1

ECD Proteins

Human LRRC32 Protein, hFc Tag

SKU:  PME100836     Target:  LRRC32

Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme100835 cxcr5 sp1

ECD Proteins

Human CXCR5 Protein, hFc Tag

SKU:  PME100835     Target:  CXCR5

Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00