| Target | |
|---|---|
| Synonyms | CD344;EVR1;FEVR;Fz-4;Fz4;FZD4S;FzE4;GPCR;hFz4 |
| Description | Recombinant Human FZD4 with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q9ULV1 |
| Expression Host | HEK293 |
| Tag | C-Human Fc Tag |
| Molecular Characterization | FZD4(Phe37-Glu180) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 42.4 kDa after removal of the signal peptide. The apparent molecular mass of FZD4-hFc is approximately 55-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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