Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme c100043 cd73 sp1

ECD Proteins

Cynomolgus CD73 Protein, His Tag

SKU:  PME-C100043     Target:  CD73

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme c100042 fap sp1

ECD Proteins

Cynomolgus FAP Protein, His Tag

SKU:  PME-C100042     Target:  FAP

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100041 tim3 sp1

ECD Proteins

Cynomolgus TIM3 Protein, hFc Tag

SKU:  PME-C100041     Target:  TIM3

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme c100040 folr1 sp1

ECD Proteins

Cynomolgus FOLR1 Protein, His Tag

SKU:  PME-C100040     Target:  FOLR1

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100039 mesothelin sp1

ECD Proteins

Cynomolgus Mesothelin Protein, His Tag

SKU:  PME-C100039     Target:  Mesothelin

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100034 micb sp1

ECD Proteins

Cynomolgus MICB Protein, His Tag

SKU:  PME-C100034     Target:  MICB

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme c100027 mica sp1

ECD Proteins

Cynomolgus MICA Protein, His Tag

SKU:  PME-C100027     Target:  MICA

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-PME C100052 CD30 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CD30 Protein, His Tag

SKU:  PME-C100052     Target:  CD30

Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00

sp-PME C100029 CDH17 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CDH17 Protein, His Tag

SKU:  PME-C100029     Target:  CDH17

Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00

sp-PME C100038 TIGIT Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus TIGIT Protein, hFc Tag

SKU:  PME-C100038     Target:  TIGIT

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100037 CD3E Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CD3E Protein, hFc Tag

SKU:  PME-C100037     Target:  CD3E

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100036 EGFR Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus EGFR Protein, His Tag

SKU:  PME-C100036     Target:  EGFR

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100035 PSMA Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus PSMA Protein, His Tag

SKU:  PME-C100035     Target:  PSMA

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100033 CEACAM5 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CEACAM5 Protein, His Tag

SKU:  PME-C100033     Target:  CEACAM5

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100032 CA9 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CA9 Protein, His Tag

SKU:  PME-C100032     Target:  CA9

Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00

sp-PME C100031 B7 H6 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus B7-H6 Protein, His Tag

SKU:  PME-C100031     Target:  B7-H6

Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00

sp-PME C100030 CD7 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CD7 Protein, hFc Tag

SKU:  PME-C100030     Target:  CD7

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100028 CD24 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus CD24 Protein, hFc Tag

SKU:  PME-C100028     Target:  CD24

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100025 AXL Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus AXL Protein, His Tag

SKU:  PME-C100025     Target:  AXL

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100024 TREM2 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus TREM2 Protein, hFc Tag

SKU:  PME-C100024     Target:  TREM2

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100023 4 1BB Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus 4-1BB Protein, hFc Tag

SKU:  PME-C100023     Target:  4-1BB

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100022 GUCY2C Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus GUCY2C Protein, His Tag

SKU:  PME-C100022     Target:  GUCY2C

Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00

sp-PME C100021 PD L1 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus PD-L1 Protein, His Tag

SKU:  PME-C100021     Target:  PDL1

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100020 5T4 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus 5T4 Protein, His Tag

SKU:  PME-C100020     Target:  5T4

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100019 TNFSF15 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus TNFSF15 Protein, hFc Tag

SKU:  PME-C100019     Target:  TNFSF15

Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00

sp-PME C100018 B7 H3 Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus B7-H3 Protein, His Tag

SKU:  PME-C100018     Target:  B7-H3

Price: 10μg ￥799.00; 50μg ￥2666.00 ; 100 μg ￥3999.00

sp-PME C100017 ALPP Fig.1 SDS PAGE 1

ECD Proteins

Cynomolgus ALPP Protein, His Tag

SKU:  PME-C100017     Target:  ALPP

Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00

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sp-PME M100111 PROM1 Fig.1 SDS PAGE 1

ECD Proteins

Mouse PROM1 Protein, hFc Tag

SKU:  PME-M100111     Target:  PROM1

Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100μg ￥3499.00

sp-PME M100110 IL23A Fig.1 SDS PAGE 1

ECD Proteins

Mouse IL23A Protein, hFc Tag

SKU:  PME-M100110     Target:  IL23A

Price: 10μg ￥690.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-PME M100109 GIPR Fig.1 SDS PAGE 1

ECD Proteins

Mouse GIPR Protein, hFc Tag

SKU:  PME-M100109     Target:  GIPR

Price: 10μg ￥600.00 ; 50μg ￥2199.00 ; 100μg ￥3299.00

sp-PME M100108 NECTIN 4 Fig.1 SDS PAGE 1

ECD Proteins

Mouse Nectin-4 Protein, His Tag

SKU:  PME-M100108     Target:  Nectin-4

Price: 10μg ￥600.00 ; 50μg ￥2199.00 ; 100μg ￥3299.00

sp-PME M100107 CCR2 Fig.1 SDS PAGE 1

ECD Proteins

Mouse CCR2 Protein, hFc Tag

SKU:  PME-M100107     Target:  CCR2

Price: 10μg ￥600.00 ; 50μg ￥2199.00 ; 100μg ￥3299.00