Extracellular Domain Protein (ECD)

DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc. 

Applications:

  • Immunogens for antibody drug development
  • Reagents used for CAR-T positive cell monitoring
  • Reagents for antibody screening and functional testing
  • Reagents for antibody affinity measurement
View All ECD Proteins

Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.

They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.

Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.

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DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.

All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.

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In recent years, the biopharmaceutical market is growing rapidly.

Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.

Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.

Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.

The List of ECD Proteins

sp-pme101437 cd209 sp1

ECD Proteins

Human CD209 Protein, His Tag

SKU:  PME101437     Target:  CD209

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101436 cmklr1 sp1

ECD Proteins

Human CMKLR1 Protein, hFc Tag

SKU:  PME101436     Target:  CMKLR1

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100 μg ￥3160.00

sp-pme101435 cd300a sp1

ECD Proteins

Human CD300A Protein, hFc Tag

SKU:  PME101435     Target:  CD300A

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100 μg ￥3160.00

sp-pme101434 pth sp1

ECD Proteins

Human PTH Protein, hFc Tag

SKU:  PME101434     Target:  PTH

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100 μg ￥3160.00

sp-pme101432 pld4 sp1

ECD Proteins

Human PLD4 Protein, hFc Tag

SKU:  PME101432     Target:  PLD4

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101431 clec7a sp1

ECD Proteins

Human CLEC7A Protein, hFc Tag

SKU:  PME101431     Target:  CLEC7A

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101430 ttr sp1

ECD Proteins

Human TTR Protein, hFc Tag

SKU:  PME101430     Target:  TTR

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100 μg ￥3160.00

sp-pme101429 fstl3 sp1

ECD Proteins

Human FSTL3 Protein, hFc Tag

SKU:  PME101429     Target:  FSTL3

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme101428 crth2 sp1

ECD Proteins

Human CRTH2 Protein, hFc Tag

SKU:  PME101428     Target:  CRTH2

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100 μg ￥3160.00

sp-pme101427 cxcr6 sp1

ECD Proteins

Human CXCR6 Protein, hFc Tag

SKU:  PME101427     Target:  CXCR6

Price: 10μg ￥630.00 ; 50μg ￥2250.00 ; 100 μg ￥3160.00

sp-pme101426 bdkrb2 sp1

ECD Proteins

Human BDKRB2 Protein, hFc Tag

SKU:  PME101426     Target:  BDKRB2

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101404 cgrpr and ramp1 sp1

ECD Proteins

Human CGRPR and RAMP1 Heterodimer Protein, hFc Tag and mFc Tag

SKU:  PME101404     Target:  CGRPR and RAMP1

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme101383 cd33 sp1

ECD Proteins

Human CD33(18-259) Protein, His Tag

SKU:  PME101383     Target:  CD33

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3500.00

sp-pme101374 lingo1 sp1

ECD Proteins

Human LINGO1 Protein, His Tag

SKU:  PME101374     Target:  LINGO1

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme100315 ki67 sp1

ECD Proteins

Human KI67(1206-1238) Protein, hFc Tag

SKU:  PME100315     Target:  KI67

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme d100009 pd l1 sp1

ECD Proteins

Canine PD-L1 Protein, hFc Tag

SKU:  PME-D100009     Target:  PDL1

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme d100008 pd 1 sp1

ECD Proteins

Canine PD-1 Protein, hFc Tag

SKU:  PME-D100008     Target:  PD-1

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme d100007 pd l1 sp1

ECD Proteins

Canine PD-L1 Protein, mFc Tag

SKU:  PME-D100007      Target:  PDL1

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme d100006 pd 1 sp1

ECD Proteins

Canine PD-1 Protein, mFc Tag

SKU:  PME-D100006     Target:  PD-1

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme d100005 pd 1 sp1

ECD Proteins

Canine PD-1 Protein, His Tag

SKU:  PME-D100005     Target:  PD-1

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme c100056 lag3 sp1

ECD Proteins

Cynomolgus LAG3 Protein, hFc Tag

SKU:  PME-C100056     Target:  LAG3

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100055 cd79b sp1

ECD Proteins

Cynomolgus CD79B Protein, hFc Tag

SKU:  PME-C100055     Target:  CD79B

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme c100054 cd3d and cd3e sp1

ECD Proteins

Cynomolgus CD3D and CD3E Heterodimer Protein, His Tag and hFc Tag

SKU:  PME-C100054     Target:  CD3D and CD3E

Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00

sp-pme c100053 cd3d sp1

ECD Proteins

Cynomolgus CD3D Protein, His Tag

SKU:  PME-C100053     Target:  CD3D

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme c100051 her3 sp1

ECD Proteins

Cynomolgus HER3 Protein, His Tag

SKU:  PME-C100051     Target:  HER3

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme c100050 cldn18.2 sp1

ECD Proteins

Cynomolgus CLDN18.2 Protein, hFc Tag

SKU:  PME-C100050     Target:  CLDN18.2

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100049 cxcr3 sp1

ECD Proteins

Cynomolgus CXCR3 Protein, hFc Tag

SKU:  PME-C100049     Target:  CXCR3

Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00

sp-pme c100048 cd47 sp1

ECD Proteins

Cynomolgus CD47 Protein, hFc Tag

SKU:  PME-C100048     Target:  CD47

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100047 b7 h4 sp1

ECD Proteins

Cynomolgus B7-H4 Protein, His Tag

SKU:  PME-C100047     Target:  B7-H4

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100046 trop2 sp1

ECD Proteins

Rhesus macaque Trop2 Protein, His Tag

SKU:  PME-C100046     Target:  Trop2

Price: 10μg ￥821.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00

sp-pme c100045 nectin 4 sp1

ECD Proteins

Cynomolgus Nectin-4 Protein, His Tag

SKU:  PME-C100045     Target:  Nectin-4

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00

sp-pme c100044 cdh6 sp1

ECD Proteins

Cynomolgus CDH6 Protein, His Tag

SKU:  PME-C100044     Target:  CDH6

Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00