DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
The List of ECD Proteins
ECD Proteins
SKU: PME100511 Target: BCMA
Price: 10μg ￥854.00 ; 50μg ￥3133.00 ; 100 μg ￥4699.00
ECD Proteins
SKU: PME100399 Target: ROR1
Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
ECD Proteins
SKU: PME100349 Target: MICA
Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00
ECD Proteins
SKU: PME100238 Target: EPHA2
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100217 Target: CSPG4
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100691 Target: LAMA4
Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
ECD Proteins
SKU: PME100115 Target: PMEL
Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
ECD Proteins
SKU: PME100100 Target: TNFSF11
Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00
ECD Proteins
SKU: PME100060 Target: DLL3
Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
ECD Proteins
SKU: PME100111 Target: VEGFA
Price: 10μg ￥818.00 ; 50μg ￥2999.00 ; 100 μg ￥4499.00
ECD Proteins
SKU: PME100108 Target: CD44
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME100510 Target: B7-H6
Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
ECD Proteins
SKU: PME100509 Target: CD10
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME100672 Target: TIM1
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME100508 Target: CB1
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100507 Target: CB1
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME100490 Target: ACE2
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100273 Target: HVEM
Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00
ECD Proteins
SKU: PME100173 Target: CD171
Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00
ECD Proteins
SKU: PME100152 Target: CA9
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100123 Target: 5T4
Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00
ECD Proteins
SKU: PME100109 Target: IL6R
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100106 Target: MUC1
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100105 Target: TNFSF12
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME100047 Target: B7-1
Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00
ECD Proteins
SKU: PME101101 Target: ZP3
Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00
ECD Proteins
SKU: PME101100 Target: ENPP3
Price: 10μg ￥727.00 ; 50μg ￥2700.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME101093 Target: NRG1
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME101092 Target: HGF
Price: 10μg ￥782.00 ; 50μg ￥2866.00 ; 100 μg ￥4299.00
ECD Proteins
SKU: PME101091 Target: CCR8
Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00
ECD Proteins
SKU: PME101089 Target: CD79B
Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00
ECD Proteins
SKU: PME101088 Target: IL21
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00