G蛋白偶联受体（GPCRs）

简介

G蛋白偶联受体（G protein-coupled receptors, GPCR）是一大类具有保守七跨膜结构的细胞表面受体。它可将激素、神经递质、趋化因子、脂质、代谢物及各类感官刺激等胞外信号，通过G蛋白与β-抑制蛋白介导的信号通路，转化为细胞内应答反应。作为细胞通讯的核心调控因子，GPCR广泛参与免疫调控、肿瘤生物学、代谢稳态、神经科学、心血管功能及炎症反应等生理过程，也是现代药物研发中最重要的靶点家族之一。
缔码生物按研究方向对热门GPCR靶点进行分类整合，涵盖免疫细胞迁移、癌症与肿瘤免疫学、代谢及内分泌疾病、血管与纤维化相关研究等领域。同时，缔码生物依托自主创新型nanodisc膜蛋白开发平台、单B细胞抗体开发平台等平台开发了一系列GPCR研究工具，包括全长膜蛋白、流式抗体、参照抗体及稳转细胞株，可全方位助力GPCR靶向药物研究。
热门靶点分类 GPCR相关产品 电子资料
the structure of GPCRs

The structure of GPCRs

热门靶点分类

为帮助科研人员更高效地梳理这一庞大多样的靶点家族，这里没有按结构分类，而是按主要研究方向对热门GPCR靶点进行归类整理。每个分类下均列出代表性靶点，这些靶点与当下药物研发热点高度相关。

免疫细胞迁移调控白细胞迁移、组织浸润，以及机体对炎症和肿瘤相关信号的应答反应。GPCR是该过程的关键调控分子，其中以CCR/CXCR等趋化因子受体、以及C5AR1、C5AR2等补体受体最为重要。这类靶点广泛应用于免疫学、肿瘤学、炎症机制研究及抗体研发领域。

C-X-C chemokine receptor type 4 (CXCR4)

  • Aliases: CD184, Fusin, LESTR
  • Indication: Hematologic malignancies; tumor metastasis
Explore the blog of CXCR4

Atypical chemokine receptor 3 (ACKR3)

  • Aliases: CXCR7, RDC1
  • Indication: cancer progression; angiogenesis
Explore the blog of CXCR7

C-C chemokine receptor type 8 (CCR8)

  • Aliases: CD198, CMKBR8
  • Indication: Treg-targeted solid tumor immunotherapy
Explore the blog of CCR8

C-C motif chemokine receptor 1 (CCR1)

  • Aliases: CD191, CMKBR1
  • Indication: Autoimmune and Inflammatory Diseases
Explore the blog of CCR1

C-C chemokine receptor type 2 (CCR2)

  • Aliases: CD192, MCP-1R, CKR2
  • Indication: Inflammatory disease; fibrosis

C-X-C chemokine receptor type 3 (CXCR3)

  • Aliases: CD183, GPR9
  • Indication: Autoimmune disease; T cell-mediated inflammation

Complement C5a receptor 1 (C5AR1)

  • Aliases: C5aR, CD88
  • Indication: Complement-mediated inflammation

Complement C5a receptor 2 (C5AR2)

  • Aliases: C5L2, GPR77
  • Indication: Sepsis; inflammatory disease

代谢类GPCR参与调控葡萄糖稳态、胰岛素分泌、食欲、能量平衡、脂质代谢及激素信号传导。这些靶点与糖尿病、肥胖症、代谢综合征以及新一代减重药物研发密切相关。

G protein-coupled receptor 75 (GPR75)

  • Indication: Obesity
Explore the Blog of GPR75

Glucagon receptor (GCGR)

  • Aliases: GCG receptor
  • Indication: Obesity; metabolic disease
Explore the Blog of GCGR

Neuropeptide Y receptor Y2 (NPY2R)

  • Aliases: NPY Y2 receptor, Y2 receptor
  • Indication: Obesity; appetite regulation
Explore the Blog of NPY2R

G protein-coupled receptor 84 (GPR84)

  • Aliases: EX33
  • Indication: Metabolic inflammation; fibrosis
Explore the Blog of GPR84

Melanocortin 4 receptor (MC4R)

  • Aliases: MC4 receptor
  • Indication: Obesity; appetite regulation
Explore the Blog of MC4R

Glucose-dependent insulinotropic receptor (GPR119)

  • Aliases: G-protein coupled receptor 119
  • Indication: Type 2 diabetes

许多GPCR参与肿瘤进展、免疫抑制、Wnt/Hedgehog信号通路以及抗体类疗法开发。GPRC5D、FZD10等靶点与抗体药物、T细胞衔接器、CAR-T策略以及实体瘤和血液肿瘤研究密切相关。

Frizzled class receptor 10 (FZD10)

  • Aliases: Frizzled-10, Fz-10, CD350
  • Indication: Solid tumors

Prostaglandin E receptor 4 (PTGER4)

  • Aliases: EP4, PGE2 receptor EP4
  • Indication: Cancer inflammation; immuno-oncology

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)

  • Aliases: GPR49, HG38
  • Indication: Colorectal cancer; cancer stem cells

这些参与调控血管张力、内皮功能、组织重塑、纤维化及炎症修复反应的GPCR，在心血管疾病、肺动脉高压、呼吸系统疾病、慢性炎症及抗纤维化药物研发中具有重要意义。

Adrenoceptor beta 2 (ADRB2)

  • Aliases: β2AR, Beta-2 adrenergic receptor, B2AR
  • Indication: Asthma; COPD

Lysophosphatidic acid receptor 1 (LPAR1)

  • Aliases: LPA1, EDG2, VZG1
  • Indication: Idiopathic pulmonary fibrosis

Sphingosine-1-phosphate receptor 1 (S1PR1)

  • Aliases: S1P1, EDG1, CD363
  • Indication: Multiple sclerosis; autoimmune disease

产品

缔码生物提供一体化GPCR研究解决方案，支持靶点验证、抗体发现、功能筛选及药物开发。依托膜蛋白制备、细胞功能验证及抗体试剂开发等技术平台，缔码生物为复杂GPCR靶点研究提供可靠的工具与支持。

*Search by gene name, alias, UniProt ID, or product SKU. Can’t find what you need? Contact us for custom development.

Nanodisc Proteins

page-flp120182a bril mc2r strep sp1

Human BRIL-MC2R-Strep full length protein-synthetic nanodisc

SKU:  FLP120182A     Target:  MC2R     Tag:  C-Flag&Strep Tag

Price:10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

page-flp120481a bril taar1 strep sp1

Human BRIL-TAAR1-Strep full length protein-synthetic nanodisc

SKU:  FLP120481A     Target:  TAAR1     Tag:  C-Flag&Strep Tag

Price:10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

page-flp100031c bril gpr75 sp1

Human BRIL-GPR75 full length protein-synthetic nanodisc

SKU:  FLP100031C     Target:  GPR75     Tag:  C-Flag Tag

Price: 10 μg ￥6300.00 ; 50 μg ￥30000.00 ; 100 μg ￥55000.00

page-flp120289 gprc5c sp1

Human GPRC5C-Strep full length protein-synthetic nanodisc

SKU:  FLP120289     Target:  GPRC5C     Tag:  C-Flag&Strep Tag

Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

page-flp100031a gpr75 sp1

Human beta2AR-GPR75-BRIL full length protein-synthetic nanodisc

SKU:  FLP100031A     Target:  GPR75     Tag:  C-Flag Tag

Price: 10 μg ￥6300.00 ; 50 μg ￥30000.00 ; 100 μg ￥55000.00

page-flp110031 gpr75 sp1

Human MBP-GPR75 full length protein-synthetic nanodisc

SKU:  FLP110031     Target:  GPR75     Tag:  N-MBP Tag, C-Flag Tag

Price: 10 μg ￥6300.00 ; 50 μg ￥30000.00 ; 100 μg ￥55000.00

page-flp120462 s1pr3 strep sp1 1

Human S1PR3-Strep full length protein-synthetic nanodisc

SKU:  FLP120462     Target:  S1PR3     Tag:  C-Flag&Strep Tag

Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

page-flp120461 s1pr2 strep sp1

Human S1PR2-Strep full length protein-synthetic nanodisc

SKU:  FLP120461     Target:  S1PR2     Tag:  C-Flag&Strep Tag

Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

点击查看所有Nanodisc蛋白！

Stable Cell Lines

fc-cel100110 hu gpr75 c strep cho s cell line flow

Hu_GPR75 C-Strep CHO-S Cell Line Pool

SKU:  CEL100110     Target:  GPR75

Application:  FACS Data

Price: Inquiry

fc-cel100109 hu gpr75 n strep cho s cell line flow

Hu_GPR75 N-Strep CHO-S Cell Line

SKU:  CEL100109     Target:  GPR75

Application:  FACS Data

Price: Inquiry

fc-cel100098 hu tshr 293t cell line flow

Hu_TSHR 293T Cell Line

SKU:  CEL100098     Target:  TSHR

Application:  FACS Data

Price: Inquiry

fc-cel100092 hu gpr75 cho s cell line flow

Hu_GPR75 CHO-S Cell Line

SKU:  CEL100092     Target:  GPR75

Application:  FACS Data

Price: Inquiry

fc-cel100096 hu gpr87 293t cell line flow

Hu_GPR87 293T Cell Line

SKU:  CEL100096     Target:  GPR87

Application:  FACS Data

Price: Inquiry

fc-cel100090 hu ccr5 k562 cell line flow

Hu_CCR5 K562 Cell Line

SKU:  CEL100090     Target:  CCR5

Application:  FACS Data

Price: Inquiry

fc-cel100088 hu ccr2 k562 cell line flow

Hu_CCR2 K562 Cell Line

SKU:  CEL100088     Target:  CCR2

Application:  FACS Data

Price: Inquiry

fc-cel100075 hu ccr4 cho s cell line flow

Hu_CCR4 CHO-S Cell Line

SKU:  CEL100075     Target:  CCR4

Application:  FACS Data

Price: Inquiry

点击查看所有稳转细胞株！

FACS-Validated Antibodies

占位

Anti-HEL Rabbit IgG1 Isotype Control antibody

SKU:  DME101359     Target:  HEL Rabbit IgG1

Application:  N/A

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dmc101768 cldn18.2 fc2

Anti-CLDN18.2 antibody(353A3), IgG1 Chimeric mAb

SKU:  DMC101768     Target:  CLDN18.2

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dmc101767 cldn18.2 fc2

Anti-CLDN18.2 antibody(355F5), IgG1 Chimeric mAb

SKU:  DMC101767     Target:  CLDN18.2

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-dme905594 flag tag figure5

Anti-DDK (FLAG) Antibody (OTIR5G2)，Rabbit mAb

SKU:  DME905594     Target:  FLAG tag

Application:  ELISA；FC；IF；IHC；IP；WB

Price: 100ul ￥2300.00

antibody-dme900039 ha tag figure2

Anti-HA Antibody (CB051)，Mouse mAb

SKU:  DME900039     Target:  HA tag

Application:  WB

Price: 100ug ￥3900.00

antibody-dme900010 gst tag figure1

Anti-GST Antibody (2A4)，Mouse mAb

SKU:  DME900010     Target:  GST tag

Application:  WB

Price: 100ul ￥2300.00

antibody-dme900009 v5 tag figure1

Anti-V5 Antibody (7E11)，Mouse mAb

SKU:  DME900009     Target:  V5 tag

Application:  WB

Price: 100ul ￥2300.00

antibody-dme900038 asred2 figure1

Anti-AsRed2 Antibody (OTI2E2)，Mouse mAb

SKU:  DME900038     Target:  AsRed2

Application:  WB

Price: 100ug ￥3900.00

点击查看所有流式抗体！

Reference Antibodies

FC-bme100297 lgr5 fc1

Anti-LGR5(petosemtamab biosimilar) mAb

SKU:  BME100297     Target:  LGR5

Application:  Flow Cyt

Price: 50 μg ￥800.00 ; 100 μg ￥1500.00

Elisa-bme100283 cxcr3 elisa1

Anti-CXCR3 (53Hu37 biosimilar)mAb

SKU:  BME100283     Target:  CXCR3

Application:  ELISA, Flow Cyt

Price:50 μg ￥800.00 ; 100 μg ￥1500.00

Elisa-bme100277 nk1r elisa1

Anti-Substance P(biosimilar) mAb

SKU:  BME100277     Target:  NK1R

Application:  ELISA

Price: 50 μg ￥800.00 ; 100 μg ￥1500.00

Elisa-bme100265 gprc5d elisa1

Anti-GPRC5D(MCARH109 biosimilar) mAb

SKU:  BME100265     Target:  GPRC5D

Application:  ELISA, Flow Cyt

Price: 50 μg ￥800.00 ; 100 μg ￥1500.00

FC-bme100080b tshr fc1

Biotinylated Anti-TSHR (K1-70) mAb

SKU:  BME100080B     Target:  TSHR

Application:  Flow Cyt

Price:100μg ￥1699.00

FC-bme100079b tshr fc1

Biotinylated Anti-TSHR (M22) mAb

SKU:  BME100079B     Target:  TSHR

Application:  Flow Cyt

Price:100μg ￥1699.00

FC-bme100209 gipr fc1

Anti-GIPR(maridebart biosimilar) mAb

SKU:  BME100209     Target:  GIPR

Application:  ELISA, Flow Cyt

Price: 50 μg ￥800.00 ; 100 μg ￥1500.00

FC-bme100204 ccr5 fc1

Anti-CCR5(leronlimab biosimilar) mAb

SKU:  BME100204     Target:  CCR5

Application:  Flow Cyt

Price: 50 μg ￥800.00 ; 100 μg ￥1500.00

点击查看所有参照抗体！

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