药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品针对靶点：

2B4	4-1BB	4-1BB-L	SIRPα
B7-H3	BCMA	CD123	CD48
CD138	CD22	CD27	GITR Ligand
CD28	CD38	CD47	CS1
GPRC5D	CTLA-4	MSLN	TROP2
GITR	TIM3	B7-2	PSCA
NKp30	BTN3A1	DNAM1	B7-H2
CD40

产品优势：

高亲和力、高特异性的兔流式单抗

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图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株，选择度高

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图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

Monoclonal Antibodies

Biotinylated Anti-FZD4 antibody(10E10), IgG1 Chimeric mAb

SKU: DMC101111B Target: FZD4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-Dxd antibody(1E6); Rabbit mAb

SKU: DME101027B Target: Dxd

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-Dxd antibody(1A12); Rabbit mAb

SKU: DME101026B Target: Dxd

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-Dxd antibody(1A1); Rabbit mAb

SKU: DME101024B Target: Dxd

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAb

SKU: DME101023B Target: CL2A

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CL2A(ADC linker) antibody(1G9); Rabbit mAb

SKU: DME101022B Target: CL2A

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CL2A(ADC linker) antibody(1H6); Rabbit mAb

SKU: DME101021B Target: CL2A

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-SN38 antibody(1G1); Rabbit mAb

SKU: DME101020B Target: SN38

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-NEFL(89-400) antibody(6D8), Rabbit mAb

SKU: DME100791B Target: NEFL

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-NEFL(89-400) antibody(6C10), Rabbit mAb

SKU: DME100790B Target: NEFL

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-NEFL(89-400) antibody(6C5), Rabbit mAb

SKU: DME100789B Target: NEFL

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-NEFL(9-88) antibody(7D10), Rabbit mAb

SKU: DME100787B Target: NEFL

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-NEFL(9-88) antibody(7D8), Rabbit mAb

SKU: DME100788B Target: NEFL

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-NEFL(9-88) antibody(7D5), Rabbit mAb

SKU: DME100786B Target: NEFL

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GFAP(68-377) antibody(21H9), Rabbit mAb

SKU: DME100800B Target: GFAP

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GFAP(68-377) antibody(21C2), Rabbit mAb

SKU: DME100798B Target: GFAP

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GFAP(68-377) antibody(17G10), Rabbit mAb

SKU: DME100264B Target: GFAP

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GFAP(68-377) antibody(17E6), Rabbit mAb

SKU: DME100263B Target: GFAP

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GFAP(68-377) antibody(17C1), Rabbit mAb

SKU: DME100801B Target: GFAP

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GFAP(7-66) antibody(1E11), Rabbit mAb

SKU: DME100803B Target: GFAP

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-UCHL1 antibody(2G7), Rabbit mAb

SKU: DME100266B Target: UCHL1

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-UCHL1 antibody(2B3), Rabbit mAb

SKU: DME100265B Target: UCHL1

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-UCHL1 antibody(2A4), Rabbit mAb

SKU: DME100843B Target: UCHL1

Application: ELISA; WB

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-ROR1 antibody(172B7), IgG1 Chimeric mAb

SKU: DMC100253B Target: ROR1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CSF1R antibody(9A5), IgG1 Chimeric mAb

SKU: DMC100382B Target: CSF1R

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-SEZ6 antibody(31A10), IgG1 Chimeric mAb

SKU: DMC101096B Target: SEZ6

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TFRC antibody(7C1), IgG1 Chimeric mAb

SKU: DMC101095B Target: TFRC

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-B7H7 antibody(2D5), IgG1 Chimeric mAb

SKU: DMC101094B Target: B7H7

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD147 antibody(2D2), IgG1 Chimeric mAb

SKU: DMC101093B Target: CD147

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-PGLYRP1 antibody(1E10), IgG1 Chimeric mAb

SKU: DMC101092B Target: PGLYRP1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-PVRIG antibody(6G7), IgG1 Chimeric mAb

SKU: DMC101091B Target: PVRIG

Application: ELISA, Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD3E antibody(1G2), IgG1 Chimeric mAb

SKU: DMC101085B Target: CD3E

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00