药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品针对靶点：

2B4	4-1BB	4-1BB-L	SIRPα
B7-H3	BCMA	CD123	CD48
CD138	CD22	CD27	GITR Ligand
CD28	CD38	CD47	CS1
GPRC5D	CTLA-4	MSLN	TROP2
GITR	TIM3	B7-2	PSCA
NKp30	BTN3A1	DNAM1	B7-H2
CD40

产品优势：

高亲和力、高特异性的兔流式单抗

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图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株，选择度高

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图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

Monoclonal Antibodies

Biotinylated Anti-CDH6 antibody(DMC675); IgG1 Chimeric mAb

SKU: DMC100675B Target: CDH6

Application: Flow Cyt; WB

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD74 antibody(DMC674), IgG1 Chimeric mAb

SKU: DMC100674B Target: CD74

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CRTAM antibody(DMC673); IgG1 Chimeric mAb

SKU: DMC100673B Target: CRTAM

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb

SKU: DMC100500B Target: HBEGF

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXCL1 antibody(DMC499); IgG1 Chimeric mAb

SKU: DMC100499B Target: CXCL1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GDNF antibody(DMC498); IgG1 Chimeric mAb

SKU: DMC100498B Target: GDNF

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GPA33 antibody(DMC497); IgG1 Chimeric mAb

SKU: DMC100497B Target: GPA33

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-LILRB2 antibody(DMC496); IgG1 Chimeric mAb

SKU: DMC100496B Target: LILRB2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-YAP1 antibody(DMC495); IgG1 Chimeric mAb

SKU: DMC100495B Target: YAP1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD32a antibody(DMC494); IgG1 Chimeric mAb

SKU: DMC100494B Target: CD32a

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-MUC1 antibody(DMC493), IgG1 Chimeric mAb

SKU: DMC100493B Target: MUC1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CRTAM antibody(DMC489); IgG1 Chimeric mAb

SKU: DMC100489B Target: CRTAM

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-FZD10 antibody(DMC487); IgG1 Chimeric mAb

SKU: DMC100487B Target: FZD10

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD23 antibody(DMC486); IgG1 Chimeric mAb

SKU: DMC100486B Target: CD23

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CDH1 antibody(DMC484); IgG1 Chimeric mAb

SKU: DMC100484B Target: CDH1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CHI3L1 antibody(DMC483); IgG1 Chimeric mAb

SKU: DMC100483B Target: CHI3L1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GPR77 antibody(DMC482); IgG1 Chimeric mAb

SKU: DMC100482B Target: C5AR2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-ADGRE1 antibody(DMC481); IgG1 Chimeric mAb

SKU: DMC100481B Target: ADGRE1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-DDR1 antibody(DMC480); IgG1 Chimeric mAb

SKU: DMC100480B Target: DDR1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-APCDD1 antibody(DMC479); IgG1 Chimeric mAb

SKU: DMC100479B Target: APCDD1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CCR6 antibody(DMC477); IgG1 Chimeric mAb

SKU: DMC100477B Target: CCR6

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD164 antibody(DMC476); IgG1 Chimeric mAb

SKU: DMC100476B Target: CD164

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-SIGLEC7 antibody(DMC475); IgG1 Chimeric mAb

SKU: DMC100475B Target: SIGLEC7

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GDF15 antibody(DMC474); IgG1 Chimeric mAb

SKU: DMC100474B Target: GDF15

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EMCN antibody(DMC473); IgG1 Chimeric mAb

SKU: DMC100473B Target: EMCN

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EPHA4 antibody(DMC472); IgG1 Chimeric mAb

SKU: DMC100472B Target: EPHA4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL22 antibody(DMC471); IgG1 Chimeric mAb

SKU: DMC100471B Target: IL22

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXCR1 antibody(DMC470); IgG1 Chimeric mAb

SKU: DMC100470B Target: CXCR1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CLEC9A antibody(DMC469); IgG1 Chimeric mAb

SKU: DMC100469B Target: CLEC9A

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CLEC1A antibody(DMC468); IgG1 Chimeric mAb

SKU: DMC100468B Target: CLEC1A

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TGFBR2 antibody(DMC467); IgG1 Chimeric mAb

SKU: DMC100467B Target: TGFBR2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CSPG4 antibody(DMC466); IgG1 Chimeric mAb

SKU: DMC100466B Target: CSPG4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00