药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品针对靶点：

2B4	4-1BB	4-1BB-L	SIRPα
B7-H3	BCMA	CD123	CD48
CD138	CD22	CD27	GITR Ligand
CD28	CD38	CD47	CS1
GPRC5D	CTLA-4	MSLN	TROP2
GITR	TIM3	B7-2	PSCA
NKp30	BTN3A1	DNAM1	B7-H2
CD40

产品优势：

高亲和力、高特异性的兔流式单抗

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图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株，选择度高

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图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

Monoclonal Antibodies

Biotinylated Anti-EPHA3 antibody(DM162); Rabbit mAb

SKU: DME100162B Target: EPHA3

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CLEC12A antibody(DM165); Rabbit mAb

SKU: DME100165B Target: CLEC12A

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD40 Ligand antibody(DM164); Rabbit mAb

SKU: DME100164B Target: CD40 Ligand

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL2RA antibody(DM148); Rabbit mAb

SKU: DME100148B Target: IL2RA

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EPCAM antibody(DM147); Rabbit mAb

SKU: DME100147B Target: EPCAM

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD155 antibody(DM146); Rabbit mAb

SKU: DME100146B Target: CD155

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD46 antibody(DM145); Rabbit mAb

SKU: DME100145B Target: CD46

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CB1 antibody(DM144); Rabbit mAb

SKU: DME100144B Target: CB1

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-BAFF-R antibody(DM143); Rabbit mAb

SKU: DME100143B Target: BAFF-R

Application: ELISA; Flow Cyt; IHC

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TNFSF12 antibody(DM141); Rabbit mAb

SKU: DME100141B Target: TNFSF12

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TNFSF12 antibody(DM140); Rabbit mAb

SKU: DME100140B Target: TNFSF12

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-5T4 antibody(DM139); Rabbit mAb

SKU: DME100139B Target: 5T4

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-5T4 antibody(DM138); Rabbit mAb

SKU: DME100138B Target: 5T4

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-5T4 antibody(DM137); Rabbit mAb

SKU: DME100137B Target: 5T4

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD34 antibody(DM136); Rabbit mAb

SKU: DME100136B Target: CD34

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD34 antibody(DM135); Rabbit mAb

SKU: DME100135B Target: CD34

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD34 antibody(DM134); Rabbit mAb

SKU: DME100134B Target: CD34

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-HVEM antibody(DM133); Rabbit mAb

SKU: DME100133B Target: HVEM

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-HVEM antibody(DM132); Rabbit mAb

SKU: DME100132B Target: HVEM

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-HVEM antibody(DM131); Rabbit mAb

SKU: DME100131B Target: HVEM

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EGFR antibody(DM130); Rabbit mAb

SKU: DME100130B Target: EGFR

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EGFR antibody(DM129); Rabbit mAb

SKU: DME100129B Target: EGFR

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-BAFF-R antibody(DM127); Rabbit mAb

SKU: DME100127B Target: BAFF-R

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL17RA antibody(DM126); Rabbit mAb

SKU: DME100126B Target: IL17RA

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL17RA antibody(DM125); Rabbit mAb

SKU: DME100125B Target: IL17RA

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-PD-L1 antibody(DM124); Rabbit mAb

SKU: DME100124B Target: PDL1

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-PD-L1 antibody(DM123); Rabbit mAb

SKU: DME100123B Target: PDL1

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CEACAM5 antibody(DM122); Rabbit mAb

SKU: DME100122B Target: CEACAM5

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CEACAM5 antibody(DM121); Rabbit mAb

SKU: DME100121B Target: CEACAM5

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CEACAM5 antibody(DM120); Rabbit mAb

SKU: DME100120B Target: CEACAM5

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD7 antibody(DM119); Rabbit mAb

SKU: DME100119B Target: CD7

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD7 antibody(DM118); Rabbit mAb

SKU: DME100118B Target: CD7

Application: ELISA; Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00