药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品针对靶点：

2B4	4-1BB	4-1BB-L	SIRPα
B7-H3	BCMA	CD123	CD48
CD138	CD22	CD27	GITR Ligand
CD28	CD38	CD47	CS1
GPRC5D	CTLA-4	MSLN	TROP2
GITR	TIM3	B7-2	PSCA
NKp30	BTN3A1	DNAM1	B7-H2
CD40

产品优势：

高亲和力、高特异性的兔流式单抗

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图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株，选择度高

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图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

Monoclonal Antibodies

Biotinylated Anti-CCR1 antibody(DMC465); IgG1 Chimeric mAb

SKU: DMC100465B Target: CCR1

Application: Flow Cyt; WB

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TNFSF15 antibody(DMC464); IgG1 Chimeric mAb

SKU: DMC100464B Target: TNFSF15

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD142 antibody(DMC463); IgG1 Chimeric mAb

SKU: DMC100463B Target: CD142

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-PRLR antibody(DMC462); IgG1 Chimeric mAb

SKU: DMC100462B Target: PRLR

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CLU antibody(DMC461); IgG1 Chimeric mAb

SKU: DMC100461B Target: CLU

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-FGFR4 antibody(DMC460), IgG1 Chimeric mAb

SKU: DMC100460B Target: FGFR4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CCR2 antibody(DMC447); IgG1 Chimeric mAb

SKU: DMC100447B Target: CCR2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD117 antibody(DMC446), IgG1 Chimeric mAb

SKU: DMC100446B Target: CD117

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-SLAMF1 antibody(DMC445); IgG1 Chimeric mAb

SKU: DMC100445B Target: SLAMF1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-BST1 antibody(DMC444); IgG1 Chimeric mAb

SKU: DMC100444B Target: BST1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXCR7 antibody(DMC443); IgG1 Chimeric mAb

SKU: DMC100443B Target: CXCR7

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CHODL antibody(DMC442); IgG1 Chimeric mAb

SKU: DMC100442B Target: CHODL

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD5L antibody(DMC441); IgG1 Chimeric mAb

SKU: DMC100441B Target: CD5L

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-UPA antibody(DMC440); IgG1 Chimeric mAb

SKU: DMC100440B Target: UPA

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD62L antibody(DMC439); IgG1 Chimeric mAb

SKU: DMC100439B Target: CD62L

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-Nectin4 antibody(DMC438); IgG1 Chimeric mAb

SKU: DMC100438B Target: Nectin-4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-M-CSF antibody(DMC437); IgG1 Chimeric mAb

SKU: DMC100437B Target: M-CSF

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD83 antibody(DMC436); IgG1 Chimeric mAb

SKU: DMC100436B Target: CD83

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD81 antibody(DMC429); IgG1 Chimeric mAb

SKU: DMC100429B Target: CD81

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-SSTR2 antibody(DMC428); IgG1 Chimeric mAb

SKU: DMC100428B Target: SSTR2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GP6 antibody(DMC427); IgG1 Chimeric mAb

SKU: DMC100427B Target: GP6

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TSLP antibody(DMC426); IgG1 Chimeric mAb

SKU: DMC100426B Target: TSLP

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD63 antibody(DMC425); IgG1 Chimeric mAb

SKU: DMC100425B Target: CD63

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EREG antibody(DMC424), IgG1 Chimeric mAb

SKU: DMC100424B Target: EREG

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD2 antibody(DMC423); IgG1 Chimeric mAb

SKU: DMC100423B Target: CD2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IGFBP7 antibody(DMC422); IgG1 Chimeric mAb

SKU: DMC100422B Target: IGFBP7

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-FLT3LG antibody(DMC421); IgG1 Chimeric mAb

SKU: DMC100421B Target: FLT3LG

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-PMEL antibody(DMC420); IgG1 Chimeric mAb

SKU: DMC100420B Target: PMEL

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL-6 antibody(DMC419); IgG1 Chimeric mAb

SKU: DMC100419B Target: IL6

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CLEC2D antibody(DMC394); IgG1 Chimeric mAb

SKU: DMC100394B Target: CLEC2D

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL5RA antibody(DMC393); IgG1 Chimeric mAb

SKU: DMC100393B Target: IL5RA

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

antibody-dmc100392b b4galt1 elisa1

Monoclonal Antibodies

Biotinylated Anti-B4GALT1 antibody(DMC392); IgG1 Chimeric mAb

SKU: DMC100392B Target: B4GALT1

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00