药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品针对靶点：

2B4	4-1BB	4-1BB-L	SIRPα
B7-H3	BCMA	CD123	CD48
CD138	CD22	CD27	GITR Ligand
CD28	CD38	CD47	CS1
GPRC5D	CTLA-4	MSLN	TROP2
GITR	TIM3	B7-2	PSCA
NKp30	BTN3A1	DNAM1	B7-H2
CD40

产品优势：

高亲和力、高特异性的兔流式单抗

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图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株，选择度高

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图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

Monoclonal Antibodies

Biotinylated Anti-DLL3 antibody(67E6), IgG1 Chimeric mAb

SKU: DMC101089B Target: DLL3

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD93 antibody(5B10), IgG1 Chimeric mAb

SKU: DMC100345B Target: CD93

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-pTHEMIS antibody(4F2), IgG1 Chimeric mAb

SKU: DMC101054B Target: THEMIS

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CDH3 antibody(6A10); IgG1 Chimeric mAb

SKU: DMC101041B Target: CDH3

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-EGFRVIII antibody(2E12); IgG1 Chimeric mAb

SKU: DMC101040B Target: EGFRVIII

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CLEC4C antibody(12D6); IgG1 Chimeric mAb

SKU: DMC101039B Target: CLEC4C

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD98 antibody(2H8); IgG1 Chimeric mAb

SKU: DMC101038B Target: CD98

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TNFRSF1B antibody(8C4); IgG1 Chimeric mAb

SKU: DMC101037B Target: TNFRSF1B

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-FGF19 antibody(6A5); IgG1 Chimeric mAb

SKU: DMC101036B Target: FGF19

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CGRP antibody(7C1); IgG1 Chimeric mAb

SKU: DMC101035B Target: CGRP

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-BTN3A2 antibody(3G2); IgG1 Chimeric mAb

SKU: DMC101034B Target: BTN3A2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD79B antibody(52A11); IgG1 Chimeric mAb

SKU: DMC101033B Target: CD79B

Application: Flow Cyt; WB

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-MMAE antibody(9C4); Rabbit mAb

SKU: DME101005B Target: MMAE

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-MMAE antibody(8C4); Rabbit mAb

SKU: DME101004B Target: MMAE

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-MMAE antibody(8B4); Rabbit mAb

SKU: DME101003B Target: MMAE

Application: ELISA

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IL1A antibody(4G2); IgG1 Chimeric mAb

SKU: DMC101006B Target: IL1A

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CD6 antibody(1G6); IgG1 Chimeric mAb

SKU: DMC101005B Target: CD6

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GPC1 antibody(1B8); IgG1 Chimeric mAb

SKU: DMC101004B Target: GPC1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CCR5 antibody(4F6); IgG1 Chimeric mAb

SKU: DMC101003B Target: CCR5

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-APP antibody(3D7); IgG1 Chimeric mAb

SKU: DMC101002B Target: APP

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-GIPR antibody(3G5); IgG1 Chimeric mAb

SKU: DMC101001B Target: GIPR

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-IGF-1R antibody(DMC721), IgG1 Chimeric mAb

SKU: DMC100721B Target: IGF-1R

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-ENPP3 antibody(DMC720); IgG1 Chimeric mAb

SKU: DMC100720B Target: ENPP3

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-LIV-1 antibody(DMC488); IgG1 Chimeric mAb

SKU: DMC100488B Target: LIV-1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-ASGR1 antibody(DMC688), IgG1 Chimeric mAb

SKU: DMC100688B Target: ASGR1

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXADR antibody(DMC687), IgG1 Chimeric mAb

SKU: DMC100687B Target: CXADR

Application: Flow Cyt; WB; IHC

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-ALPP antibody(DMC686); IgG1 Chimeric mAb

SKU: DMC100686B Target: ALPP

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CEACAM6 antibody(DMC685); IgG1 Chimeric mAb

SKU: DMC100685B Target: CEACAM6

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-TENM4 antibody(DMC683); IgG1 Chimeric mAb

SKU: DMC100683B Target: TENM4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXCR2 antibody(DMC681); IgG1 Chimeric mAb

SKU: DMC100681B Target: CXCR2

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXCR4 antibody(DMC680), IgG1 Chimeric mAb

SKU: DMC100680B Target: CXCR4

Application: Flow Cyt

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00

Monoclonal Antibodies

Biotinylated Anti-CXCR5 antibody(DMC679), IgG1 Chimeric mAb

SKU: DMC100679B Target: CXCR5

Application: Flow Cyt; IHC

Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00