DIMA Biotechnology offers over 800 ECD proteins covering more than 600 single pass membrane protein targets. All the proteins were made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target proteins. We also implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing tests, thermal stability tests, etc.
Extracellular Domain Protein (ECD)
Applications:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
Immune checkpoint proteins
Immune checkpoints are a class of proteins that regulate tumor immune microenvironment.
They can be classified into two categories, costimulatory immune checkpoints, such as OX40, GITR, ICOS, etc.; and co-suppressive immune checkpoints, such as PD1, CTLA-4, etc.
Right now there are a number of FDA approved drugs on co-suppressive targets, such as Yervoy, anti-CTLA-4 monoclonal antibody, Keytruda, anti-PD-1 monoclonal antibody and Tecentriq, anti-PD-L1 monoclonal antibody.
Hematological cancer targets
DIMA Biotechnology LTD provide a full spectrum of functional proteins of new CAR T-cell targets.
All the proteins were made by using HEK293 mammalian cell secretion expression system and we implemented a strict quality control process, including purity testing, antibody-drug interaction verification, freezing and thawing Tests, thermal stability tests, etc.
Solid tumor targets
In recent years, the biopharmaceutical market is growing rapidly.
Compared with small molecule drugs, antibody drugs exhibit higher specificity and selectivity.
Therefore, it showed tremendous progresses in the treatment of hematological cancers and autoimmune diseases.
Due to complex tumor immune microenvironment, the development of therapeutic antibody drugs for solid tumor is more challenging.
The List of ECD Proteins
ECD Proteins
SKU: PME30070 Target: CCL14
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30068 Target: IL-4
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30064 Target: FGF-19
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30062 Target: IL-3
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30061 Target: CXCL3
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30060 Target: FGF-8b
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30059 Target: pro-Beta
Price: 10 μg ￥840.00 ; 50 μg ￥2520.00
ECD Proteins
SKU: PME30057 Target: IL-8
Price: 10 μg ￥760.00 ; 50 μg ￥2280.00
ECD Proteins
SKU: PME30056 Target: CCL8
Price: 10 μg ￥760.00 ; 50 μg ￥2280.00
ECD Proteins
SKU: PME30054 Target: CCL24
Price: 10 μg ￥760.00 ; 50 μg ￥2280.00
ECD Proteins
SKU: PME30051 Target: IL-20RB
Price: 10 μg ￥760.00 ; 50 μg ￥2000.00
ECD Proteins
SKU: PME30050 Target: IFN
Price: 10 μg ￥760.00 ; 50 μg ￥2000.00
ECD Proteins
SKU: PME30048 Target: LongIGF-II
Price: 10 μg ￥720.00 ; 50 μg ￥2000.00
ECD Proteins
SKU: PME30046 Target: FGF-4
Price: 10 μg ￥630.00 ; 50 μg ￥1890.00
ECD Proteins
SKU: PME30044 Target: CCL17
Price: 10 μg ￥600.00 ; 50 μg ￥1800.00
ECD Proteins
SKU: PME30043 Target: Noggin
Price: 10 μg ￥640.00 ; 50 μg ￥1764.00
ECD Proteins
SKU: PME30042 Target: ELAPOR1
Price: 10 μg ￥570.00 ; 50 μg ￥1700.00
ECD Proteins
SKU: PME30041 Target: SHH
Price: 10 μg ￥570.00 ; 50 μg ￥1700.00
ECD Proteins
SKU: PME30040 Target: FGFb
Price: 10 μg ￥560.00 ; 50 μg ￥1200.00
ECD Proteins
SKU: PME30038 Target: proHB-EGF
Price: 10 μg ￥400.00 ; 50 μg ￥920.00
ECD Proteins
SKU: PME30037 Target: IL-2
Price: 10 μg ￥400.00 ; 50 μg ￥1200.00
ECD Proteins
SKU: PME30036 Target: CXCL7
Price: 10 μg ￥400.00 ; 50 μg ￥1200.00
ECD Proteins
SKU: PME30033 Target: IFN
Price: 10 μg ￥400.00 ; 50 μg ￥1120.00
ECD Proteins
SKU: PME30032 Target: IFN
Price: 10 μg ￥400.00 ; 50 μg ￥1120.00
ECD Proteins
SKU: PME30031 Target: MYDGF
Price: 10 μg ￥360.00 ; 50 μg ￥840.00