药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台,聚焦肿瘤免疫靶点,使用功能活性充分验证的重组蛋白作为抗原免疫兔子,直接从阳性兔B细胞中克隆IgG,重组表达进行流式验证。这一技术不仅大大缩短了研发的时间,也让我们能够直接获得IgG的基因序列信息,而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应,覆盖多个热门肿瘤靶点:

已成功开发出5000+兔单抗产品,覆盖500余种靶点。

应用范围广泛:

产品均经过ELISA或流式验证,还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力:

兔抗体基因库具有更高多样性,更高亲和力,表位覆盖更广。

多种抗体类型:

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高:

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比,定制灵活:

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台,可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆,从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品优势:

高亲和力、高特异性的兔流式单抗

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图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株,选择度高

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图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

SKU:  DME100174P     Target:  ROR2

Application:  Flow Cyt

Price: 100 test ¥3880.00

SKU:  DME100173P     Target:  B7-H6

Application:  Flow Cyt

Price: 100 test ¥3880.00

SKU:  DME100172P     Target:  CD114

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SKU:  DME100171P     Target:  CA9

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SKU:  DME100170P     Target:  LIGHT

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SKU:  DME100168P     Target:  MICB

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SKU:  DME100167P     Target:  EPHA2

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SKU:  DME100155P     Target:  CD171

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SKU:  DME100146P     Target:  CD155

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SKU:  DME100145P     Target:  CD46

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SKU:  DME100139P     Target:  5T4

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SKU:  DME100138P     Target:  5T4

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SKU:  DME100137P     Target:  5T4

Application:  Flow Cyt

Price: 100 test ¥3880.00