缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。
已成功开发出5000+兔单抗产品，覆盖500余种靶点。
产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。
兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。
兔单抗、人兔嵌合抗体、人源化抗体等。
缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。
可提供多标签、多种属及大规格包装定制。
缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。
| 2B4 | 4-1BB | 4-1BB-L | SIRPα |
| B7-H3 | BCMA | CD123 | CD48 |
| CD138 | CD22 | CD27 | GITR Ligand |
| CD28 | CD38 | CD47 | CS1 |
| GPRC5D | CTLA-4 | MSLN | TROP2 |
| GITR | TIM3 | B7-2 | PSCA |
| NKp30 | BTN3A1 | DNAM1 | B7-H2 |
| CD40 |
A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.
Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.
Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.
Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10µg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10µg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)
A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay.
Monoclonal Antibodies
Biotinylated Anti-IGF-1R antibody(DMC721), IgG1 Chimeric mAb
SKU: DMC100721B Target: IGF-1R
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100720B Target: ENPP3
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100488B Target: LIV-1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100688B Target: ASGR1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100687B Target: CXADR
Application: Flow Cyt; WB; IHC
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100686B Target: ALPP
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-CEACAM6 antibody(DMC685); IgG1 Chimeric mAb
SKU: DMC100685B Target: CEACAM6
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100683B Target: TENM4
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100681B Target: CXCR2
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100680B Target: CXCR4
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100679B Target: CXCR5
Application: Flow Cyt; IHC
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100675B Target: CDH6
Application: Flow Cyt; WB
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100674B Target: CD74
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100673B Target: CRTAM
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100500B Target: HBEGF
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100499B Target: CXCL1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100498B Target: GDNF
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100497B Target: GPA33
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-LILRB2 antibody(DMC496); IgG1 Chimeric mAb
SKU: DMC100496B Target: LILRB2
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100495B Target: YAP1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100494B Target: CD32a
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100493B Target: MUC1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100489B Target: CRTAM
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100487B Target: FZD10
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100486B Target: CD23
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100484B Target: CDH1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-CHI3L1 antibody(DMC483); IgG1 Chimeric mAb
SKU: DMC100483B Target: CHI3L1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100482B Target: C5AR2
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-ADGRE1 antibody(DMC481); IgG1 Chimeric mAb
SKU: DMC100481B Target: ADGRE1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100480B Target: DDR1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
Biotinylated Anti-APCDD1 antibody(DMC479); IgG1 Chimeric mAb
SKU: DMC100479B Target: APCDD1
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC100477B Target: CCR6
Application: Flow Cyt
Price: 10μg ￥1030.00 ; 50μg ￥3380.00 ; 100 μg ￥6080.00 ; 500 μg ￥19880.00
