药物靶点重组单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

产品针对靶点：

2B4	4-1BB	4-1BB-L	SIRPα
B7-H3	BCMA	CD123	CD48
CD138	CD22	CD27	GITR Ligand
CD28	CD38	CD47	CS1
GPRC5D	CTLA-4	MSLN	TROP2
GITR	TIM3	B7-2	PSCA
NKp30	BTN3A1	DNAM1	B7-H2
CD40

产品优势：

高亲和力、高特异性的兔流式单抗

图 1. A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (clone: DM8). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DM8 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

单个靶点多个候选克隆株，选择度高

图 2. Affinity ranking of different Rabbit anti-CS1 mAb clones by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

Monoclonal Antibodies

Anti-SARS-CoV-2 RBD antibody(DM26); Rabbit mAb

SKU: DME100025 Target: S protein RBD

Application: ELISA; Flow Cyt

Price: 10μg ￥630.00 ; 50μg ￥1880.00 ; 100 μg ￥3380.00 ; 500 μg ￥11080.00

antibody-DME100018 SARS CoV 2 Spike S2 Figure 1

Monoclonal Antibodies

Anti-SARS-CoV-2 Spike antibody(DM25); Rabbit mAb

SKU: DME100018 Target: S protein

Application: ELISA

Price: 10μg ￥630.00 ; 50μg ￥1880.00 ; 100 μg ￥3380.00 ; 500 μg ￥11080.00

antibody-DME100017 SARS CoV 2 Spike S2 Figure 1

Monoclonal Antibodies

Anti-SARS-CoV-2 Spike antibody(DM24); Rabbit mAb

SKU: DME100017 Target: S protein

Application: ELISA

Price: 10μg ￥630.00 ; 50μg ￥1880.00 ; 100 μg ￥3380.00 ; 500 μg ￥11080.00

antibody-DME100016 SARS CoV 2 Nucleocapsid Figure 1

Monoclonal Antibodies

Anti-SARS-CoV-2 Nucleocapsid antibody(DM23); Rabbit mAb

SKU: DME100016 Target: Nucleocapsid

Application: ELISA

Price: 10μg ￥630.00 ; 50μg ￥1880.00 ; 100 μg ￥3380.00 ; 500 μg ￥11080.00

antibody-DME100015 SARS CoV 2 Nucleocapsid Figure 1

Monoclonal Antibodies

Anti-SARS-CoV-2 Nucleocapsid antibody(DM22); Rabbit mAb

SKU: DME100015 Target: Nucleocapsid

Application: ELISA

Price: 10μg ￥630.00 ; 50μg ￥1880.00 ; 100 μg ￥3380.00 ; 500 μg ￥11080.00

Monoclonal Antibodies

Anti-His Tag Antibody(DM1); Rabbit mAb

SKU: DME100001 Target: His Tag

Application: ELISA; WB

Price: 10μg ￥580.00 ; 50μg ￥1580.00 ; 100 μg ￥2795.00 ; 500 μg ￥8399.00

Monoclonal Antibodies

PE-conjugated Anti-ACVR2A antibody(15D6), IgG1 Chimeric mAb

SKU: DMC101357P Target: ACVR2A

Application: Flow Cyt

100 test ￥3880.00

Monoclonal Antibodies

PE-conjugated Anti-MET antibody(8C4), IgG1 Chimeric mAb

SKU: DMC101356P Target: MET

Application: Flow Cyt

100 test ￥3880.00

Monoclonal Antibodies

Biotinylated Anti-Rabbit IgG antibody(37A11), Goat mAb

SKU: DME101139B Target: Rabbit IgG

Application: ELISA