药物靶点重组兔单克隆抗体

缔码生物创新性的兔重组单克隆抗体平台，聚焦肿瘤免疫靶点，使用功能活性充分验证的重组蛋白作为抗原免疫兔子，直接从阳性兔B细胞中克隆IgG，重组表达进行流式验证。这一技术不仅大大缩短了研发的时间，也让我们能够直接获得IgG的基因序列信息，而无需担心杂交瘤细胞丢失。

DIMA mAbs优势

现货供应，覆盖多个热门肿瘤靶点：

已成功开发出5000+兔单抗产品，覆盖500余种靶点。

应用范围广泛：

产品均经过ELISA或流式验证，还可开发WB、IHC、IF、荧光标记等应用。

高特异性、高亲和力：

兔抗体基因库具有更高多样性，更高亲和力，表位覆盖更广。

多种抗体类型：

兔单抗、人兔嵌合抗体、人源化抗体等。

成药性高：

缔码基于单B细胞技术的兔单抗发现平台开发出来的抗体成药性高。

高性价比，定制灵活：

可提供多标签、多种属及大规格包装定制。

B细胞种子库高效筛选兔单抗

缔码生物拥有独创的DIMA mAbs重组单克隆抗体开发平台，可以在完成动物免疫后直接从外周血中获取阳性B细胞并克隆抗体基因序列。从单只免疫动物中我们可以得到上万个靶点结合阳性B细胞克隆，从中能够更为高效的筛选出具有高特异性、高亲和力重组单克隆抗体。

热门抗体靶点

2B44-1BB4-1BB-LSIRPα
B7-H3BCMACD123CD48
CD138CD22CD27GITR Ligand
CD28CD38CD47CS1
GPRC5DCTLA-4MSLNTROP2
GITRTIM3B7-2PSCA
NKp30BTN3A1DNAM1B7-H2
CD40

验证数据展示

pages-5 1

A) Flow cytometry data of serially titrated Rabbit anti-SIRPα monoclonal antibody (DME100008). The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used. B) Competition assay demonstrating DME100008 blockade of CD47 binding to THP-1 cells. IC50=30.88ng/ml.

Left: Western blot analysis of CD38 protein using Anti-CD38 antibody (Cat. DME100027) at 1:1000 dilution.

Right: Western blot analysis of CD48 protein using Anti-CD48 antibody (SKU# DME100043) at 1/1000 dilution.

Anti-CD27 antibody(DM59), Rabbit mAb (DME100059) at 10µg/ml staining CD27 in Raji cells by IHC (SKU# DME100059);B. DME100059 at 10µg/ml staining CD27 in human tonsil tissue by IHC (SKU# DME100059)

A: The scheme of Anti-BCMA BiTE molecule (Cat. DMB100003). B: Tumor cell killing assay. 

pages-6 2

Affinity ranking of different Rabbit anti-CS1 mAb clones (DM9, DM10, DM11) by titration of different concentration onto Raji cells. The Y-axis represents the mean fluorescence intensity (MFI) while the X-axis represents the concentration of IgG used.

单克隆抗体

antibody-DMC100369 Her2 Flow Fig1

Monoclonal Antibodies

Anti-HER2 antibody(DMC369); IgG1 Chimeric mAb

SKU:  DMC100369     Target:  Her2

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100367 ICAM1 Flow Fig1

Monoclonal Antibodies

Anti-ICAM-1 antibody(DMC367); IgG1 Chimeric mAb

SKU:  DMC100367     Target:  ICAM-1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100393 IL5RA Flow Fig1

Monoclonal Antibodies

Anti-IL5RA antibody(DMC393); IgG1 Chimeric mAb

SKU:  DMC100393     Target:  IL5RA

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100392 B4GALT1 Flow Fig1

Monoclonal Antibodies

Anti-B4GALT1 antibody(DMC392); IgG1 Chimeric mAb

SKU:  DMC100392     Target:  B4GALT1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100390 FOLR2 Flow Fig1

Monoclonal Antibodies

Anti-FOLR2 antibody(DMC390); IgG1 Chimeric mAb

SKU:  DMC100390     Target:  FOLR2

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100389 VWF Flow Fig1

Monoclonal Antibodies

Anti-VWF antibody(DMC389); IgG1 Chimeric mAb

SKU:  DMC100389     Target:  VWF

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100388 EDA Flow Fig1

Monoclonal Antibodies

Anti-EDA antibody(DMC388); IgG1 Chimeric mAb

SKU:  DMC100388     Target:  EDA

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100387 GUCY2C Flow Fig1

Monoclonal Antibodies

Anti-GUCY2C antibody(DMC387); IgG1 Chimeric mAb

SKU:  DMC100387     Target:  GUCY2C

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100371 GPC3 Flow Fig1

Monoclonal Antibodies

Anti-GPC3 antibody(DMC371); IgG1 Chimeric mAb

SKU:  DMC100371     Target:  GPC3

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100370 ADGRE2 Flow Fig1

Monoclonal Antibodies

Anti-ADGRE2 antibody(DMC370); IgG1 Chimeric mAb

SKU:  DMC100370     Target:  ADGRE2

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100368 GPR75 Flow Fig1

Monoclonal Antibodies

Anti-GPR75 antibody(DMC368); IgG1 Chimeric mAb

SKU:  DMC100368     Target:  GPR75

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100366 CFB Flow Fig1

Monoclonal Antibodies

Anti-CFB antibody(DMC366); IgG1 Chimeric mAb

SKU:  DMC100366     Target:  CFB

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100299 B7H5 Flow Fig1

Monoclonal Antibodies

Anti-B7-H5 antibody(DMC299); IgG1 Chimeric mAb

SKU:  DMC100299     Target:  B7-H5

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100286 SLAMF5 Flow Fig1

Monoclonal Antibodies

Anti-SLAMF5 antibody(DMC286); IgG1 Chimeric mAb

SKU:  DMC100286     Target:  SLAMF5

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100285 CD96 Flow Fig1

Monoclonal Antibodies

Anti-CD96 antibody(DMC285); IgG1 Chimeric mAb

SKU:  DMC100285     Target:  CD96

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100280 CD21 Flow Fig1

Monoclonal Antibodies

Anti-CD21 antibody(DMC280); IgG1 Chimeric mAb

SKU:  DMC100280     Target:  CD21

Application:  Flow Cyt; WB

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100278 JAM A Flow Fig1

Monoclonal Antibodies

Anti-JAM-A antibody(DMC278); IgG1 Chimeric mAb

SKU:  DMC100278     Target:  JAM-A

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100269 CD44 Flow Fig1

Monoclonal Antibodies

Anti-CD44 antibody(DMC269); IgG1 Chimeric mAb

SKU:  DMC100269     Target:  CD44

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DME100009 CS1 FLOW Fig1 left

Monoclonal Antibodies

Anti-CS1 antibody(DM9); Rabbit mAb

SKU:  DME100009     Target:  CS1

Application:  ELISA; Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DME100008 SIRPA FLOW Fig1 A

Monoclonal Antibodies

Anti-SIRPa(DM8) antibody; Rabbit mAb

SKU:  DME100008     Target:  SIRPa

Application:  ELISA; Flow Cyt; IF; IP

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100298 NKG2A Flow Fig1

Monoclonal Antibodies

Anti-NKG2A antibody(DMC298); IgG1 Chimeric mAb

SKU:  DMC100298     Target:  NKG2A

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100297 CCR4 Flow Fig1

Monoclonal Antibodies

Anti-CCR4 antibody(DMC297); IgG1 Chimeric mAb

SKU:  DMC100297     Target:  CCR4

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100287 NKG2D Flow Fig1

Monoclonal Antibodies

Anti-NKG2D antibody(DMC287); IgG1 Chimeric mAb

SKU:  DMC100287     Target:  NKG2D

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100284 IL4RA Flow Fig1

Monoclonal Antibodies

Anti-IL4RA antibody(DMC284); IgG1 Chimeric mAb

SKU:  DMC100284     Target:  IL4RA

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100283 CD162 Flow Fig1 1

Monoclonal Antibodies

Anti-CD162 antibody(DMC283); IgG1 Chimeric mAb

SKU:  DMC100283     Target:  SELPLG

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100282 IL11RA Flow Fig1

Monoclonal Antibodies

Anti-IL11RA antibody(DMC282); IgG1 Chimeric mAb

SKU:  DMC100282     Target:  IL11RA

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100281 AFP Flow Fig1

Monoclonal Antibodies

Anti-AFP antibody(DMC281); IgG1 Chimeric mAb

SKU:  DMC100281     Target:  AFP

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100279 Galectin 9 Flow Fig1

Monoclonal Antibodies

Anti-Galectin 9 antibody(DMC279); IgG1 Chimeric mAb

SKU:  DMC100279     Target:  Galectin 9

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100277 LGALS1 Flow Fig1

Monoclonal Antibodies

Anti-LGALS1 antibody(DMC277); IgG1 Chimeric mAb

SKU:  DMC100277     Target:  LGALS1

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100276 VEGFA Flow Fig1

Monoclonal Antibodies

Anti-VEGFA antibody(DMC276); IgG1 Chimeric mAb

SKU:  DMC100276     Target:  VEGFA

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100275 ALB Flow Fig1

Monoclonal Antibodies

Anti-ALB antibody(DMC275); IgG1 Chimeric mAb

SKU:  DMC100275     Target:  ALB

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

antibody-DMC100274 IL5 Flow Fig1

Monoclonal Antibodies

Anti-IL5 antibody(DMC274); IgG1 Chimeric mAb

SKU:  DMC100274     Target:  IL5

Application:  Flow Cyt

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00