Clone ID | DMC484 |
---|---|
Target | |
Synonyms | Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO |
Host Species | Rabbit |
Description | Anti-CDH1 antibody(DMC484); IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | P12830 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants; at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats; a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric; breast; colorectal; thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation; invasion; and:or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq; Nov 2015] |
Usage | Research use only |
Conjugate | Unconjugated |
Anti-CDH1 antibody(DMC484); IgG1 Chimeric mAb
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Product Data
图片
Figure 1. Flow cytometry analysis with Anti-CDH1 (DMC484) on Expi293 cells transfected with human CDH1 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human CDH1 mAb( DMC100484).
(A) DMC100484 does not bind to CHO-S cells that do not express CDH1.
(B) A clear peak shift of DMC100484 was seen compared to the control when incubated with CDH1-expressing A431 cells, indicating strong binding of DMC100484 to CDH1. Antibodies were incubated at 5 μg/mL.
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