Biosimilar参照抗体

在生物药研发中,抗体药物研发无疑是最受关注的焦点,是增长最快的细分领域之一,已成为生物药中最重要的一大品类。在抗体药物开发过程中,头对头的质量可比性研究更是重中之重。通常临床阶段及上市抗体药分子是大家首选的对标参照。

缔码生物功能活性蛋白表达平台利用HEK293哺乳动物细胞分泌表达系统,重组表达了众多热门靶点的biosimilar参照抗体,便利广大科研工作者进行相关开发过程中的对比研究,同时也可以辅佐验证靶点蛋白的功能活性。

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产品数据展示:

 

活性蛋白检测

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Figure 1. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human PD1, mFc-His tagged protein (PME100025) can bind Anti-PD-1 Neutralizing antibody in a linear range of 0.24-6.49 ng/ml.

流式功能检测对比

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Figure 2. HEK293 cell line transfected with irrelevant protein and human PD1 were surface stained with anti-PD1 neutralizing antibody 1μg/ml (pembrolizumab) followed by Alexa 488-conjugated anti-human IgG secondary antibody.

Biosimilar参照抗体列表

Biosimilar reference antibodies

PE-conjugated Anti-FLT1(icrucumab biosimilar) mAb

SKU:  BME100131P     Target:  FLT1

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100130P     Target:  GM-CSF

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100128P     Target:  PSMA

Application:  Flow Cyt

Price: 100 test ¥1360.00

Biosimilar reference antibodies

PE-conjugated Anti-CCL2(carlumab biosimilar) mAb

SKU:  BME100125P     Target:  CCL2

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100112P     Target:  TSLP

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100107P     Target:  DKK1

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100095P     Target:  PCSK9

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100105P     Target:  CCN2

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100129P     Target:  CD73

Application:  Flow Cyt

Price: 100 test ¥1360.00

Biosimilar reference antibodies

PE-conjugated Anti-SSTR2(tidutamab) mAb

SKU:  BME100127P      Target:  SSTR2

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100124P     Target:  CD142

Application:  Flow Cyt

Price: 100 test ¥1360.00

Biosimilar reference antibodies

PE-conjugated Anti-IL9(enokizumab biosimilar) mAb

SKU:  BME100122P     Target:  IL9

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100117P     Target:  IFNAR1

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100116P     Target:  IL1B

Application:  Flow Cyt

Price: 100 test ¥1360.00

Biosimilar reference antibodies

PE-conjugated Anti-CCR8(BMS 986340) mAb

SKU:  BME100115P     Target:  CCR8

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100120P     Target:  C5AR1

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100119P     Target:  NRP1

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100090P     Target:  GDF15

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100114P     Target:  IL22

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100109P     Target:  B7-H5

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100099P     Target:  NOTCH3

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100106P     Target:  AMHR2

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100104P     Target:  M-CSF

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100102P     Target:  CD56

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100101P     Target:  CXCR4

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100100P     Target:  CEACAM6

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100097P     Target:  IL1A

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100085P     Target:  NKG2A

Application:  Flow Cyt

Price: 100 test ¥1360.00

Biosimilar reference antibodies

PE-conjugated Anti-CD19(FMC63 biosimilar) mAb

SKU:  BME100094P     Target:  CD19

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100091P     Target:  GFRA3

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100089P     Target:  FCRL5

Application:  Flow Cyt

Price: 100 test ¥1360.00

SKU:  BME100087P     Target:  CCR2

Application:  Flow Cyt

Price: 100 test ¥1360.00