缔码新品|快人一步抢先试用-Anti-Dxd抗体和Anti-SN38抗体
活动时间：2024年2月21日-3月31日
活动对象：终端客户
试用活动产品：DME101025&DME101020
| 货号 | 名称 | 产品类型 |
| DME101025 | Anti-Dxd antibody(1A5); Rabbit mAb | DimAb monoclonal antibodies |
| DME101020 | Anti-SN38 antibody(1G1); Rabbit mAb | DimAb monoclonal antibodies |
DXd，DX-8951衍生物，是一种新型的、高膜透性拓扑异构酶I抑制剂。DXd抗肿瘤活性强，在血液中的半衰期较短，有利于减少毒副作用的产生；此外，DXd具有强大的细胞膜渗透能力，产生旁观者效应，可杀灭临近的肿瘤细胞，且半衰期缩短。
SN-38，又称为7-ethyl-10-hydroxycamptothecin，是一种半合成喜树碱。SN-38是伊立替康代谢产物，也是其主要的抗肿瘤成分，抑制活性比伊立替康强2到3个数量级。
目前，缔码已开发出多个payload抗体，包括Anti-MMAE抗体、Anti-Dxd抗体和Anti-SN38抗体。这些抗体在众多药物测试中展现了显著功效，在推进ADC开发方面拥有巨大潜力。
Figure 1. Elisa plates were pre-coated with IgG-Dxd (0.2μg/per well). Serial diluted anti-Dxd monoclonal antibody (DME101025) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Dxd monoclonal antibody binding with IgG-Dxd is 3.447ng/ml.
Figure 2. Elisa plates were pre-coated with IgG-SN38 (0.2μg/per well). Serial diluted anti-SN38 monoclonal antibody (DME101020) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-SN38 monoclonal antibody binding with IgG-SN38 is 11.39ng/ml.
缔码生物现针对Anti-Dxd抗体和Anti-SN38抗体发起试用活动，欢迎有需要的客户扫描以下二维码填写申请表单，参与活动免费领取试用装。
活动说明：
1、活动对象：终端客户（数量有限，先到先得）；
2、该活动不与其他优惠同享；
3、本活动最终解释权归缔码生物科技有限公司所有；
4、提交申请表单后会有缔码工作人员与您联系。