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HER2/ERBB2重组蛋白、流式抗体及IHC研究工具
HER2，又称ERBB2，是ERBB受体酪氨酸激酶家族成员，与EGFR、HER3和HER4共同构成重要的细胞生长信号网络。HER2本身缺乏明确的高亲和力可溶性配体，但其胞外结构倾向于形成适于二聚化的构象，因此能够作为其他ERBB受体的重要二聚化伙伴。HER2激活后可增强PI3K/AKT和RAS/MAPK等通路，促进细胞增殖、生存和迁移。ERBB2基因扩增或蛋白高表达可见于乳腺、胃及多种其他实体瘤，使HER2成为肿瘤靶向研究中最成熟的细胞表面靶点之一。围绕HER2的研究已从受体阻断扩展到ADC、双/多特异性抗体及不同表达水平肿瘤的精准靶向，对抗体表位、内吞和表达定量提出更高要求。更多关于HER2靶向疗法最新研究进展>>
缔码生物提供多种HER2 ECD重组蛋白及不同标签形式，可用于ELISA、抗体筛选、亲和力评价和表位研究。Flow Cyt验证兔单抗及丰富的Biosimilar参照抗体可用于细胞表面HER2检测、候选分子比较和方法开发，并提供标记形式用于直接流式和捕获实验；DiSliceX™肿瘤组织切片则可支持IHC条件优化和组织表达评价。相关蛋白和抗体资源还可与ADC内吞和功能验证平台衔接。
DiSliceX
SKU: SLI100018 Target: 5T4, DDR1, Her2, LIV-1
Application: IHC
Price: 2 slides ￥899.00
ECD Proteins
SKU: PME-C100074 Target: Her2 Tag: C-10×His tag
Expression Host: HEK293
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
Monoclonal Antibodies
SKU: DMC100369 Target: Her2
Application: Flow Cyt
Price: 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Biosimilar reference antibodies
SKU: BME100048 Target: Her2
Application: ELISA; Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
ECD Proteins
SKU: PME100665 Target: Her2 Tag: C-Human Fc Tag
Expression Host: HEK293
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
ECD Proteins
SKU: PME100095 Target: Her2 Tag: C-6×His Tag
Expression Host: HEK293
Price: 10μg ￥727.00 ; 50μg ￥2666.00 ; 100 μg ￥3999.00
Biosimilar reference antibodies
SKU: BME100048P Target: Her2
Application: Flow Cyt
Price: 100 test ￥1360.00
Biosimilar reference antibodies
SKU: BME100616B Target: Her2
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100564B Target: Her2
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100563B Target: Her2
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100459B Target: Her2
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100449B Target: Her2
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100446B Target: Her2
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100616 Target: Her2
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100564 Target: Her2
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100563 Target: Her2
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100459 Target: Her2
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100449 Target: Her2
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100446 Target: Her2
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100048B Target: Her2
Application: ELISA; Flow Cyt
Price:100μg ￥1699.00
