HER3/ERBB3重组蛋白抗体
人类表皮生长因子受体3(HER3),也称为受体酪氨酸蛋白激酶ERBB3,是一种膜结合蛋白,属于ERBB/HER受体酪氨酸激酶(RTK)家族。HER3 广泛表达于人类成人组织,包括胃肠道、泌尿道、呼吸道、生殖道、皮肤、内分泌和神经系统的细胞。与其他ERBB受体酪氨酸激酶家族成员不同,它们在与配体结合后可以通过自身磷酸化而被激活,而ERBB3存在激酶缺陷,其自身磷酸化活性仅为EGFR的1/1000,并且没有磷酸化其他蛋白质的能力。更多HER3作用机制>>
虽然没有证据表明HER3过表达、组成性激活或突变本身会致癌,但其作为HER2的二聚体伙伴,与生长、增殖、化疗耐药以及促进侵袭和转移有关。目前已在多种类型肿瘤中发现HER3表达或过表达,比如乳腺癌、卵巢癌、肺癌、结肠癌、胰腺癌、黑色素瘤、胃癌和头颈癌等。
为助力HER3生物疗法的开发,缔码生物可提供HER3靶点全系列产品与服务。产品包括活性蛋白、参照抗体和流式验证单克隆抗体;服务包括多种属蛋白抗体定制服务、抗体人源化和亲和力成熟服务。此外,缔码还制备了HER3靶点单B细胞种子库,最快28天可获得先导抗体分子;同时,我们目前已筛选出有22个HER3先导分子,其中有18个验证了人猴蛋白交叉反应,客户第二天可以拿到分子进行功能评估验证;针对部分分子,我们也正在进行ADC内吞活性及杀伤验证,具体数据欢迎垂询。
Monoclonal Antibodies
SKU: DME101059 Target: HER3
Application: IHC
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Overexpression Stable Cell Line
SKU: CEL100032 Target: HER3
Application: FACS Data
Price: Inquiry
DiSliceX
SKU: SLI100004 Target: ADAM9, AFP, ALB, ANGPTL3, B7H3, CD112, CD24, CDH6, CLDN6, CLU, CXADR, GPC3, HER3, MSLN, PRLR, SCF
Application: IHC
Price: 2 slides ¥899.00
Biosimilar reference antibodies
SKU: BME100244 Target: HER3
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Monoclonal Antibodies
SKU: DME100580 Target: HER3
Application: IHC; Flow Cyt
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Monoclonal Antibodies
SKU: DME100433 Target: HER3
Application: WB
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
ECD Proteins
SKU: PME101443 Target: HER3
Price: 10μg ¥706.00 ; 50μg ¥2500.00 ; 100μg ¥3699.00
ECD Proteins
SKU: PME-C100051 Target: HER3
Price: 10μg ¥706.00 ; 50μg ¥2500.00 ; 100μg ¥3699.00
ECD Proteins
SKU: PME101412 Target: HER3
Price: 10μg ¥600.00 ; 50μg ¥2199.00 ; 100μg ¥3299.00
ECD Proteins
SKU: PME101411 Target: HER3
Price: 10μg ¥600.00 ; 50μg ¥2199.00 ; 100μg ¥3299.00
Monoclonal Antibodies
SKU: DME100175 Target: HER3
Application: ELISA; Flow Cyt
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Biosimilar reference antibodies
SKU: BME100057 Target: HER3
Application: ELISA; Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
ECD Proteins
SKU: PME100088 Target: HER3
Price: 10μg ¥818.00 ; 50μg ¥2999.00 ; 100 μg ¥4499.00
Monoclonal Antibodies
SKU: DME100580P Target: HER3
Application: Flow Cyt
Price: 100 test ¥3880.00
Monoclonal Antibodies
SKU: DME100175P Target: HER3
Application: Flow Cyt
Price: 100 test ¥3880.00
Biosimilar reference antibodies
SKU: BME100244P Target: HER3
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100057P Target: HER3
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100586B Target: HER3
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100586 Target: HER3
Application: N/A
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Monoclonal Antibodies
SKU: DME101059B Target: HER3
Application: IHC
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00