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PD-1/PDCD1重组蛋白、流式抗体及研究工具

程序性死亡受体1（Programmed Cell Death Protein 1，PD-1），基因名为PDCD1，也被命名为CD279，是表达于活化 T 细胞表面的经典抑制性免疫检查点分子，可调控T细胞活化、效应功能及免疫耐受，因此是肿瘤免疫和免疫调控研究中的核心靶点之一。在治疗疾病领域，PD-1相关研究和药物开发目前仍以肿瘤为主，常见方向包括非小细胞肺癌、黑色素瘤、头颈鳞状细胞癌、膀胱癌、肾细胞癌、霍奇金淋巴瘤等。靶向PD-1的药物开发已形成以单克隆抗体为主、双特异性抗体持续扩展的格局。更多药物类型与研究进展，可延伸阅读《PD-1靶向药物类型全梳理》《PD-1 vs PD-L1：免疫检查点靶向机制差异》和《PD-1/PD-L1：肿瘤免疫检查点核心通路解析》。

缔码生物提供覆盖人、小鼠、犬、猴等不同种属的PD-1 ECD重组蛋白，并提供hFc、mFc、His、Fc-His及生物素化等多种标签或修饰形式，同时提供兔单克隆抗体、大量Biosimilar参照抗体以及PE/生物素标记抗体。不同种属和标签形式的PD-1蛋白可用于蛋白互作、ELISA、抗体筛选、结合活性、亲和力评价、表位研究及跨种属反应性分析；单抗和参照抗体可用于ELISA、Flow Cyt、细胞表面PD-1检测及方法开发；PE偶联抗体适用于直接流式分析，生物素化蛋白及抗体则便于构建基于生物素-亲和素体系的结合与筛选实验。

依托单B细胞抗体发现、DiLibrary™抗体工程及体外功能验证平台，缔码生物还可进一步支持PD-1抗体的候选分子筛选、人源化、亲和力成熟及免疫检查点相关功能评价，为PD-1/PDCD1靶向抗体及多特异性分子研发提供配套支持。

Biosimilar reference antibodies

Biotinylated Anti-PD-1(zeluvalimab biosimilar) mAb

SKU: BME100738B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(toripalimab biosimilar) mAb

SKU: BME100703B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(tislelizumab biosimilar) mAb

SKU: BME100700B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(spartalizumab biosimilar) mAb

SKU: BME100676B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(sintilimab biosimilar) mAb

SKU: BME100668B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(serplulimab biosimilar) mAb

SKU: BME100665B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(sasanlimab biosimilar) mAb

SKU: BME100663B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(rosnilimab biosimilar) mAb

SKU: BME100657B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(retifanlimab biosimilar) mAb

SKU: BME100646B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(pucotenlimab biosimilar) mAb

SKU: BME100629B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(prolgolimab biosimilar) mAb

SKU: BME100628B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(pradusinstobart biosimilar) mAb

SKU: BME100625B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(pimivalimab biosimilar) mAb

SKU: BME100619B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(pidilizumab biosimilar) mAb

SKU: BME100618B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Elisa-bme100615b pd 1 elisa1

Biosimilar reference antibodies

Biotinylated Anti-PD-1(peresolimab biosimilar) mAb

SKU: BME100615B Target: PD-1

Application: ELISA

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(penpulimab biosimilar) mAb

SKU: BME100613B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(nofazinlimab biosimilar) mAb

SKU: BME100591B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Elisa-bme100590b pd 1 elisa1

Biosimilar reference antibodies

Biotinylated Anti-PD-1(nivolumab biosimilar) mAb

SKU: BME100590B Target: PD-1

Application: ELISA

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(iparomlimab biosimilar) mAb

SKU: BME100539B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

Biosimilar reference antibodies

Biotinylated Anti-PD-1(geptanolimab biosimilar) mAb

SKU: BME100521B Target: PD-1

Application: N/A

Price:100μg ￥1699.00

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