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CDH17重组蛋白、抗体及研究工具
钙黏蛋白17（Cadherin-17，CDH17），又称肝肠钙粘蛋白（LI-cadherin）或人肽转运蛋白-1 (HPT-1)，是钙黏蛋白超家族中的膜蛋白，具有多个胞外Cadherin结构域。CDH17在正常组织中的表达主要集中于胃肠道上皮等组织，而在多种胃肠道来源实体瘤中可出现异常或较高表达，因此成为ADC、双/多特异性抗体、细胞治疗等肿瘤靶向策略的重要候选靶点。更多关于CDH17作用机制>>
针对CDH17靶点，缔码生物已建立包括多种胞外区域ECD重组蛋白、生物素化蛋白、兔单克隆抗体、Biosimilar参照抗体、CDH17过表达K562稳转细胞株以及DiSliceX™组织切片在内的研究工具矩阵。不同区域和不同标签的CDH17蛋白可用于ELISA、抗体筛选、表位研究、亲和力评价及跨种属反应性分析；单抗和参照抗体适用于ELISA、Flow Cyt、WB及候选抗体比较；稳转细胞株可用于FACS、细胞结合和功能抗体筛选；DiSliceX™组织切片可支持IHC条件优化和组织表达评价。
除研究试剂外，缔码生物针对CDH17已筛选获得数十个先导抗体分子，其中部分候选分子已验证人/猴交叉反应性，并可直接用于后续功能评价；部分分子正在进一步开展ADC内吞活性及细胞杀伤验证。客户可基于现有先导分子及配套数据快速启动功能验证，并进一步衔接人源化、亲和力成熟及抗体工程优化。
ECD Proteins
SKU: PME100801B Target: CDH17 Tag: C-6×His Avi Tag
Expression Host: HEK293
Price: 10μg ￥735.00 ; 50μg ￥2749.00 ; 100μg ￥4125.00
Biosimilar reference antibodies
SKU: BME100291 Target: CDH17
Application: ELISA, Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100290 Target: CDH17
Application: Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100289 Target: CDH17
Application: ELISA, Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
ECD Proteins
SKU: PME101842 Target: CDH17 Tag: C-Mouse Fc tag
Expression Host: HEK293
Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00
ECD Proteins
SKU: PME101841 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00
Biosimilar reference antibodies
SKU: BME100262 Target: CDH17
Application: ELISA, Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
ECD Proteins
SKU: PME101623 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
ECD Proteins
SKU: PME101608 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100 μg ￥3499.00
Overexpression Stable Cell Line
SKU: CEL100009 Target: CDH17
Application: FACS Data
Price: Inquiry
ECD Proteins
SKU: PME101567 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
ECD Proteins
SKU: PME101566 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00
ECD Proteins
SKU: PME101565 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
ECD Proteins
SKU: PME101564 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00
ECD Proteins
SKU: PME101563 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥668.00 ; 50μg ￥2300.00 ; 100μg ￥3499.00
ECD Proteins
SKU: PME101562 Target: CDH17 Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
Biosimilar reference antibodies
SKU: BME100233 Target: CDH17
Application: ELISA, Flow Cyt
Price:50 μg ￥800.00 ; 100 μg ￥1500.00
Monoclonal Antibodies
SKU: DMC100637 Target: CDH17
Application: WB; Flow Cyt
price: 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Biosimilar reference antibodies
SKU: BME100198 Target: CDH17
Application: ELISA, Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
ECD Proteins
SKU: PME-C100029 Target: CDH17 Tag: C-10×His tag
Expression Host: HEK293
Price: 10μg ￥668.00; 50μg ￥2310.00 ; 100 μg ￥3499.00
