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CD19全长蛋白抗体与细胞株
CD19，又称为Leu-12，是B细胞谱系最经典的细胞表面分子之一，从较早期 B 细胞发育阶段开始表达，并持续存在于大多数成熟B细胞，而在浆细胞阶段逐渐降低。作为B细胞受体信号复合体系的重要调节分子，CD19可调控BCR激活阈值，并参与B细胞增殖、分化和免疫应答。由于其稳定且相对谱系特异的细胞表面表达，CD19已成为B细胞恶性疾病研究中最成熟的靶点之一，被广泛用于单克隆抗体、ADC、双/多特异性抗体和工程化细胞治疗研究。对于CD19靶向分子而言，除常规ECD结合外，抗体在天然膜构象下的识别能力、不同表位分布、跨物种反应性及细胞结合特性同样非常关键。
缔码生物已建立较完整的CD19产品矩阵，包括不同区域及工程设计的ECD重组蛋白、人/猴源蛋白、生物素化蛋白、PeptiNanodisc和Synthetic Nanodisc两种全长CD19膜蛋白、流式/WB单抗、Biosimilar参照抗体、PE/生物素标记产品、CD19过表达K562稳转细胞株及DiSliceX™组织切片。ECD与全长Nanodisc蛋白可分别支持抗体筛选、表位研究及天然膜构象相关结合验证；稳转细胞株适用于FACS、Cell Binding和功能筛选；组织切片可用于IHC评价。此外，缔码还储备多个CD19先导抗体，可进一步衔接人源化、亲和力成熟和功能验证。
Biosimilar reference antibodies
SKU: BME100683P Target: CD19
Application: Flow Cyt
Price: 100 test ￥1360.00
Biosimilar reference antibodies
SKU: BME100206P Target: CD19
Application: Flow Cyt
Price: 100 test ￥1360.00
Biosimilar reference antibodies
SKU: BME100094P Target: CD19
Application: Flow Cyt
Price: 100 test ￥1360.00
Biosimilar reference antibodies
SKU: BME100051P Target: CD19
Application: Flow Cyt
Price: 100 test ￥1360.00
Biosimilar reference antibodies
SKU: BME100683B Target: CD19
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100594B Target: CD19
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100443B Target: CD19
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100594 Target: CD19
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100443 Target: CD19
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100206B Target: CD19
Application: Flow Cyt
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100094B Target: CD19
Application: Flow Cyt
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100051B Target: CD19
Application: ELISA; Flow Cyt
Price:100μg ￥1699.00
Monoclonal Antibodies
SKU: DMC100804B Target: CD19
Application: WB
Price: 100 μg ￥6080.00 ; 500 μg ￥19880.00
Monoclonal Antibodies
SKU: DMC101150B Target: CD19
Application: Flow Cyt
Price: 100 μg ￥6080.00 ; 500 μg ￥19880.00
