AXL重组蛋白抗体
AXL,又名 Ark,Ufo和Tyro-7,是一种受体酪氨酸激酶,最初是Liu E等人1988年在筛选粒细胞白血病(CML)慢性转急性相关的基因时发现的。正常生理条件下,AXL的表达大多局限于正常细胞中的平滑肌、肺、肾、睾丸和血液。在对许多癌细胞的研究中发现,AXL在非小细胞肺癌、乳腺癌、卵巢癌等多种癌症中高表达,与肿瘤的发生、发展以及耐药密切相关。
AXL与其他TAM 家族受体一样,为了响应炎症反应等各种生物过程,一般是通过经典的配体结合整合细胞外信号,从而诱导有效的细胞内信号传导。而AXL激活存在两种方式,一种是经典的配体依赖性激活(为主),一种是非Gas6依赖性激活。AXL经典的配体依赖性激活指的是AXL/Gas6信号通路。AXL受体的非Gas6依赖性激活指的是AXL与另外2个TAM受体(Mer和Tyro-3)和其他几种非TAM家族成员蛋白(如:EGFR、HER2等)相互作用来激活。更多关于AXL作用机制及信号通路>>
据Clinical trail数据展示,目前靶向AXL的临床药还是以小分子化合物为主,以免疫疗法为基础的药只有5款,3款ADC,1款CAR-T,1款抗体。为了加速AXL靶点药物研发,缔码现可提供AXL靶点全系列产品与服务,产品涵盖多种属活性蛋白、流式验证单抗及参照抗体。服务涵盖人源化、亲和力成熟、PTM风险位点去除。另外,缔码还针对AXL制备了B细胞种子库,最快20天可完成先导抗体分子筛选。
ECD Proteins
SKU: PME101587 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME101586 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME101585 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME101584 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME101583 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
Monoclonal Antibodies
SKU: DMC100868 Target: AXL
Application: WB
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
ECD Proteins
SKU: PME-C100025 Target: AXL
Price: 10μg ¥799.00; 50μg ¥2666.00 ; 100 μg ¥3999.00
Biosimilar reference antibodies
SKU: BME100175 Target: AXL
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
ECD Proteins
SKU: PME-M100094 Target: AXL
Price: 10μg ¥600.00 ; 50μg ¥2199.00 ; 100μg ¥3299.00
Monoclonal Antibodies
SKU: DME100158 Target: AXL
Application: ELISA; Flow Cyt
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Biosimilar reference antibodies
SKU: BME100033 Target: AXL
Application: ELISA; Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
ECD Proteins
SKU: PME100532 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME100070 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME100533 Target: AXL
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
Monoclonal Antibodies
SKU: DME100158P Target: AXL
Application: Flow Cyt
Price: 100 test ¥3880.00
Biosimilar reference antibodies
SKU: BME100175P Target: AXL
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100033P Target: AXL
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100699B Target: AXL
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100569B Target: AXL
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100699 Target: AXL
Application: N/A
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00