Tag | C-Flag&Strep Tag |
---|---|
Target | |
Synonyms | N/A |
Description | Human TRPC6-Strep full length protein-synthetic nanodisc |
Delivery | In Stock |
Uniprot ID | Q9Y210 |
Expression Host | HEK293 |
Protein Families | Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane |
Protein Pathways | N/A |
Molecular Weight | The human full length TRPC6-Strep protein has a MW of 106.3 kDa |
Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | The protein forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). |
Usage | Research use only |
Conjugate | Unconjugated |
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