| Tag | C-Flag&Strep Tag |
|---|---|
| Target | |
| Synonyms | EKNS; PFE; PTHR; PTHR1 |
| Description | Human PTH1R-Strep full length protein-synthetic nanodisc |
| Delivery | In Stock |
| Uniprot ID | Q03431 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Molecular Weight | The human full length PTH1R-Strep protein has a MW of 66.4 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human PTH1R-Strep full length protein-synthetic nanodisc
Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00
Product Data Negative control Dima FAQ
Figure 1. Elisa plates were pre-coated with C-Flag&Strep Tag PTH1R-Strep-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with PTH1R-Strep-nanodisc is 1.603ng/ml.
Figure 2. Human PTH1R-Strep-Nanodisc, C-Flag&Strep Tag on SDS-PAGE
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