| Target | |
|---|---|
| Synonyms | PFE; EKNS; PTHR; PTHR1 |
| Description | Recombinant human PTH1R Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q03431 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | PTH1R(Asp27-Gly188) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 44.8 kDa after removal of the signal peptide. The apparent molecular mass of PTH1R-hFc is approximately 55-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] |
| Usage | Research use only |
| Conjugate | Unconjugated |
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