| Tag | C-Flag&Strep Tag |
|---|---|
| Target | |
| Synonyms | BETA3AR |
| Description | Human ADRB3-Strep full length protein-synthetic nanodisc |
| Delivery | In Stock |
| Uniprot ID | P13945 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Endocytosis, Neuroactive ligand-receptor interaction |
| Molecular Weight | The human full length ADRB3-Strep protein has a MW of 43.5 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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