| Target | |
|---|---|
| Synonyms | GPCR BILF1，BLIF |
| Description | Recombinant EBVB9 BILF1 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P03208 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | BILF1(Met1-Ser37) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 29.9 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | BILF1 is a G-protein coupled receptor (GPCR) encoded by Epstein–Barr virus (EBV) and some related γ-herpesviruses. It functions as a viral GPCR homolog, mimicking host chemokine receptors. BILF1 constitutively activates Gαi signaling, leading to inhibition of cAMP accumulation and modulation of downstream pathways such as MAPK/ERK and NF-κB, thereby promoting cell survival and immune evasion. It can downregulate MHC class I molecules, reducing antigen presentation to cytotoxic T cells. Through these activities, BILF1 contributes to viral persistence and oncogenic transformation in EBV-associated malignancies. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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