| Target | |
|---|---|
| Synonyms | Integrin alpha 3 beta 1,ITGB1 and ITGA3 |
| Description | Recombinant human ITGB1 protein with C-terminal human Fc tag and human ITGA3 protein with C-terminal 10×His tag |
| Delivery | In Stock |
| Uniprot ID | P05556 and P26006 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag and C-10×His tag |
| Molecular Characterization | ITGB1(Gln21-Asp728) hFc(Glu99-Ala330) ITGA3(Phe33-Glu991) 10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 104.5 and 108.0 kDa kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Integrin alpha-3/beta-1 (α3β1) is a transmembrane receptor that binds laminin, fibronectin, collagen, epiligrin, thrombospondin, and CSPG4. It mediates cell adhesion, migration, and signaling by serving as a docking site for FAP (seprase) at invadopodia in a collagen-dependent manner, facilitating ECM degradation and promoting invasion. α3β1 also cooperates with LGALS3 to mediate CSPG4-induced endothelial cell migration and participates in tissue morphogenesis and basement membrane organization. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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