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PCSK9重组蛋白、抗体及LDLR通路研究工具
PCSK9（Proprotein Convertase Subtilisin/Kexin Type 9）是一种主要由肝脏分泌的蛋白，在胆固醇和脂蛋白代谢中发挥核心作用。PCSK9能与肝细胞表面的LDL receptor（LDLR）结合，并促进受体在内吞后进入溶酶体降解，而不是循环返回细胞膜。LDLR数量减少会降低肝脏清除血液LDL cholesterol的能力，因此PCSK9活性与循环LDL-C水平密切相关。人类遗传学研究进一步显示，不同PCSK9功能变异可显著改变LDL-C和心血管风险，为该靶点提供了强有力的遗传学验证。除了传统蛋白中和外，围绕PCSK9的研究还涉及RNA调控、基因编辑及长效抑制策略，因此PCSK9是心血管和代谢药物研发中具有代表性的靶点。
缔码生物提供人PCSK9重组蛋白，可用于PCSK9-LDLR互作、ELISA、SPR/BLI、抗体免疫、亲和力和阻断活性评价。页面同时提供ELISA/Flow Cyt验证单克隆抗体以及丰富的Biosimilar参照抗体，并具有生物素化或PE标记产品，可用于PCSK9检测、候选抗体比较、捕获分析及标准曲线/方法建立。对于中和型候选抗体，可结合PCSK9-LDLR竞争实验及细胞LDLR回收/表达体系进一步评价功能，从蛋白结合向代谢通路功能验证延伸。
Monoclonal Antibodies
SKU: DMC100222 Target: PCSK9
Application: ELISA; Flow Cyt
Price: 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Biosimilar reference antibodies
SKU: BME100095 Target: PCSK9
Application: Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
ECD Proteins
SKU: PME100562 Target: PCSK9 Tag: C-Human Fc Tag
Expression Host: HEK293
Price: 10μg ￥668.00 ; 50μg ￥2499.00 ; 100μg ￥3750.00
Biosimilar reference antibodies
SKU: BME100095P Target: PCSK9
Application: Flow Cyt
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Biosimilar reference antibodies
SKU: BME100684B Target: PCSK9
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100638B Target: PCSK9
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100604B Target: PCSK9
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100517B Target: PCSK9
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100501B Target: PCSK9
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100409B Target: PCSK9
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100684 Target: PCSK9
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100638 Target: PCSK9
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100604 Target: PCSK9
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100517 Target: PCSK9
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100501 Target: PCSK9
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100409 Target: PCSK9
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100095B Target: PCSK9
Application: Flow Cyt
Price:100μg ￥1699.00
Monoclonal Antibodies
SKU: DMC100222B Target: PCSK9
Application: ELISA; Flow Cyt
Price: 100 μg ￥6080.00 ; 500 μg ￥19880.00
