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IL-6重组蛋白、流式抗体及参照抗体
IL-6是一种多效性促炎细胞因子，可由单核/巨噬细胞、T 细胞、成纤维细胞、内皮细胞及多种组织细胞在感染、损伤或炎症刺激下产生。IL-6首先与IL-6Rα结合，随后招募信号转导亚基gp130形成受体复合物，并激活JAK/STAT3、MAPK和PI3K/AKT等通路。IL-6可通过膜型IL-6R介导经典信号，也可借助可溶性IL-6R形成trans-signaling，从而扩大能够响应IL-6的细胞范围。该通路参与急性期反应、B/T细胞分化、造血、组织修复和代谢调节，而持续异常激活则与自身免疫、慢性炎症、细胞因子失衡及部分肿瘤微环境变化密切相关。因此IL-6及其受体轴一直是细胞因子阻断抗体和炎症机制研究的重要方向。
缔码生物提供人和小鼠等不同种属IL-6重组蛋白以及不同Fc标签形式，可用于ELISA、IL-6/IL-6R互作、抗体免疫、结合评价和跨种属研究。页面同时提供ELISA/Flow Cyt验证的单克隆抗体和丰富的Biosimilar参照抗体，并具有PE或生物素标记形式，可支持IL-6检测、候选抗体比较、捕获体系建立及抗体筛选。相关产品适用于炎症细胞因子研究、阻断型抗体评价以及IL-6/IL-6R/gp130信号体系的方法开发。
ECD Proteins
SKU: PME-C100123 Target: IL6 Tag: N-10×His tag
Expression Host: HEK293
Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00
ECD Proteins
SKU: PME-M100100 Target: IL6 Tag: C-Human Fc Tag
Expression Host: HEK293
Price: 10μg ￥600.00 ; 50μg ￥2199.00 ; 100μg ￥3299.00
Monoclonal Antibodies
SKU: DMC100419 Target: IL6
Application: Flow Cyt
Price: 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
ECD Proteins
SKU: PME100032 Target: IL6 Tag: C-Mouse Fc and 6×His Tag
Expression Host: HEK293
Price: 10μg ￥909.00 ; 50μg ￥3333.00 ; 100 μg ￥4999.00
Biosimilar reference antibodies
SKU: BME100007 Target: IL6
Application: ELISA; Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100007P Target: IL6
Application: Flow Cyt
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Biosimilar reference antibodies
SKU: BME100740B Target: IL6
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100719B Target: IL6
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100669B Target: IL6
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100608B Target: IL6
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100601B Target: IL6
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100456B Target: IL6
Application: ELISA
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100740 Target: IL6
Application: ELISA
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100719 Target: IL6
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100669 Target: IL6
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100608 Target: IL6
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100601 Target: IL6
Application: N/A
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100456 Target: IL6
Application: ELISA
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100007B Target: IL6
Application: ELISA; Flow Cyt
Price:100μg ￥1699.00
Monoclonal Antibodies
SKU: DMC100419B Target: IL6
Application: Flow Cyt
Price: 100 μg ￥6080.00 ; 500 μg ￥19880.00
