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IGF-1R重组蛋白、分段ECD及流式抗体
IGF-1R（Insulin-Like Growth Factor 1 Receptor）是一种受体酪氨酸激酶，以α2β2异源四聚体形式存在于细胞膜。其主要配体为IGF-1和IGF-2，配体结合后可促进受体自磷酸化，并通过IRS、PI3K/AKT和RAS/MAPK等信号通路调节细胞生长、存活、代谢、分化和组织发育。IGF-1R与胰岛素受体具有较高结构同源性，并可形成杂合受体，因此靶向分子的选择性和表位位置对于功能及安全性评价十分重要。IGF-1R信号异常与多种肿瘤、内分泌和代谢疾病相关，同时也参与眼眶成纤维细胞等特定细胞类型的异常激活，因此仍是抗体及受体信号调节研究的重要靶点。
缔码生物提供较丰富的IGF-1R ECD及分段蛋白，包括不同结构区域和标签形式，可用于IGF配体结合、ELISA、抗体筛选、结构域识别、表位定位及受体选择性研究。Flow Cyt验证单抗和Biosimilar参照抗体可用于细胞表面IGF-1R检测、候选分子比较和方法开发，并提供部分生物素化形式以满足捕获或SPR/BLI实验需求。DiSliceX™组织切片可进一步支持IHC和组织表达评价。对于IGF-1R这类与同源受体高度相关的RTK，分段蛋白尤其适合用于候选抗体表位确认和特异性分析。
ECD Proteins
SKU: PME102010 Target: IGF-1R Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME102009 Target: IGF-1R Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME102008 Target: IGF-1R Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
ECD Proteins
SKU: PME102007 Target: IGF-1R Tag: C-10×His tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
ECD Proteins
SKU: PME101890 Target: IGF-1R Tag: C-Mouse Fc tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
ECD Proteins
SKU: PME101889 Target: IGF-1R Tag: C-Human Fc tag
Expression Host: HEK293
Price: 10μg ￥706.00 ; 50μg ￥2500.00 ; 100μg ￥3699.00
Monoclonal Antibodies
SKU: DMC100721 Target: IGF-1R
Application: Flow Cyt
Price: 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00
Biosimilar reference antibodies
SKU: BME100174 Target: IGF-1R
Application: Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
ECD Proteins
SKU: PME-M100101 Target: IGF-1R Tag: C-6×His Tag
Expression Host: HEK293
Price: 10μg ￥636.00 ; 50μg ￥2333.00 ; 100μg ￥3499.00
ECD Proteins
SKU: PME100814 Target: IGF-1R Tag: C-6×His Tag
Expression Host: HEK293
Price: 10μg ￥673.00 ; 50μg ￥2466.00 ; 100 μg ￥3699.00
Biosimilar reference antibodies
SKU: BME100174P Target: IGF-1R
Application: Flow Cyt
Price: 100 test ￥1360.00
Biosimilar reference antibodies
SKU: BME100721B Target: IGF-1R
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100556B Target: IGF-1R
Application: N/A
Price:100μg ￥1699.00
Biosimilar reference antibodies
SKU: BME100721 Target: IGF-1R
Application: Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
Biosimilar reference antibodies
SKU: BME100556 Target: IGF-1R
Application: Flow Cyt
Price: 50 μg ￥800.00 ; 100 μg ￥1500.00
DiSliceX
SKU: SLI100017 Target: B4GALT1, B7H6, CD166, CD63, CXCR4, EPHA2, FOLR1, IGF-1R, IGFBP7, LGALS1, MSLN
Application: IHC
Price: 2 slides ￥899.00
Biosimilar reference antibodies
SKU: BME100174B Target: IGF-1R
Application: Flow Cyt
Price:100μg ￥1699.00
Monoclonal Antibodies
Biotinylated Anti-IGF-1R antibody(DMC721), IgG1 Chimeric mAb
SKU: DMC100721B Target: IGF-1R
Application: Flow Cyt
Price: 100 μg ￥6080.00 ; 500 μg ￥19880.00
