FRα/FOLR1重组蛋白抗体
叶酸受体α(FRα)是叶酸受体(FR)家族中的成员之一,该家族还有三个成员,分别是FRβ、FRγ和FRδ。除FRγ外,FR家族其他成员都是通过糖基磷脂酰肌醇(GPI)锚定于细胞膜的单链糖蛋白,能够结合叶酸并通过内吞作用转运叶酸进入细胞,是叶酸转运蛋白的一种。FRɑ由基因FOLR1编码,该基因位于 11 号染色体,由7个外显子和6个内含子组成。正常情况下,FRα的组织表达有限,通常局限于极化上皮的管腔(顶端)表面,包括近端肾小管、肺部1型和2型肺细胞、脉络丛、卵巢、输卵管、子宫、子宫颈、附睾、下颌下唾液腺体、支气管腺体和胎盘中的滋养层细胞,这也使该受体不容易接触到叶酸。
FRα现已经被证实在正常细胞中几乎不表达,在实体瘤中有广泛高表达,比如间皮瘤(72-100%),三阴性乳腺癌(35-68%),卵巢癌(76-89%),非小细胞肺癌(14-74%);而非恶性组织,只有肺部顶端支气管的上皮细胞,有一定比例的表达。在肿瘤细胞中,FRα不仅可以作为叶酸转运蛋白发挥作用,还可以作为转录因子,在癌细胞增殖、转移的过程中发挥作用。更多关于FRα作用机制>>
为加速FRα生物疗法的开发,缔码生物可提供FRα靶点全系列产品与服务,产品包括活性蛋白、参照抗体和WB&FC验证单克隆抗体;服务涵盖多种属蛋白抗体定制服务、抗体人源化和亲和力成熟服务。此外,缔码还制备了FRα靶点单B细胞种子库,最快28天可获得先导抗体分子;同时,我们目前已筛选出有数十个CDH17先导分子,其中绝大部分都验证了人猴蛋白交叉反应,客户第二天可以拿到分子进行功能评估验证;针对部分分子,我们也正在进行ADC内吞活性及杀伤验证,具体数据欢迎垂询。
Overexpression Stable Cell Line
SKU: CEL100024 Target: FOLR1
Application: FACS Data
Price: Inquiry
Monoclonal Antibodies
SKU: DMC100585 Target: FOLR1
Application: WB
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
ECD Proteins
SKU: PME-M100114 Target: FOLR1
Price: 10μg ¥727.00 ; 50μg ¥2666.00 ; 100 μg ¥3999.00
ECD Proteins
SKU: PME-C100040 Target: FOLR1
Price: 10μg ¥821.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
Biosimilar reference antibodies
SKU: BME100178 Target: FOLR1
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Biosimilar reference antibodies
SKU: BME100163 Target: FOLR1
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Monoclonal Antibodies
SKU: DMC100391 Target: FOLR1
Application: Flow Cyt
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
ECD Proteins
SKU: PME100249 Target: FOLR1
Price: 10μg ¥727.00 ; 50μg ¥2666.00 ; 100 μg ¥3999.00
Monoclonal Antibodies
PE-conjugated Anti-FOLR1 antibody(DMC391); IgG1 Chimeric mAb
SKU: DMC100391P Target: FOLR1
Application: Flow Cyt
Price: 100 test ¥3880.00
Biosimilar reference antibodies
SKU: BME100178P Target: FOLR1
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100163P Target: FOLR1
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100651B Target: FOLR1
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100651 Target: FOLR1
Application: N/A
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
DiSliceX
SKU: SLI100017 Target: B4GALT1, B7H6, CD166, CD63, CXCR4, EPHA2, FOLR1, IGF-1R, IGFBP7, LGALS1, MSLN
Application: IHC
Price: 2 slides ¥899.00
Biosimilar reference antibodies
SKU: BME100178B Target: FOLR1
Application: ELISA, Flow Cyt
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100163B Target: FOLR1
Application: ELISA, Flow Cyt
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Monoclonal Antibodies
SKU: DMC100585B Target: FOLR1
Application: WB
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00
Monoclonal Antibodies
SKU: DMC100391B Target: FOLR1
Application: Flow Cyt
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00