CDH6重组蛋白抗体
钙粘附蛋白6(CDH6),又称为胎儿肾钙粘蛋白或K-钙黏蛋白,是一种由CDH6(又称为CAD6或KCAD)基因编码的蛋白质。CDH6是单次跨膜蛋白,属于II型经典钙黏蛋白,为钙粘蛋白超家族成员之一。CDH6参与胚胎肾脏的形态发生和发育,并驱动肾脏形态发生所必需的间充质-上皮分化,但在成人肾脏中,CDH6的表达非常弱。在成年人的正常组织中,CDH6的表达局限于肾脏的肾小管、胆管上皮细胞等。此外,CDH6也在血小板中表达,在血小板聚集和血栓形成中起功能性作用。该功能由RGD 基序与αIIbβ3整合素结合介导,后者发生构象变化并与纤维蛋白原结合,从而交联血小板。更多关于CDH6结构与作用>>
据报道,CDH6在甲状腺癌、胃癌、胰腺癌和卵巢癌中高表达,其中,肾癌是最早发现CDH6高表达的癌症。同时结合其在正常组织中表达受限的特点,CDH6也成为可开发靶向药的可选靶点。尽管目前全球范围内仅有三家药企布局CDH6,均为CDH6 ADC,不过已有候选产品表现出巨大潜力。为加速CDH6生物疗法的开发,缔码生物已制备好CDH6靶点全系列产品(活性蛋白、参照抗体和流式验证单克隆抗体),同时也提供多项定制服务,包括多种属蛋白抗体定制服务、抗体人源化和亲和力成熟服务。此外,缔码还制备了CDH6靶点单B细胞种子库,最快28天可获得先导抗体分子;同时,我们目前已筛选出有20+CDH6先导分子,均为人猴交叉分子,客户第二天可以拿到分子进行功能评估验证;针对部分分子,我们也正在进行ADC内吞活性及杀伤验证,具体数据欢迎垂询。
ECD Proteins
SKU: PME101674 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
ECD Proteins
SKU: PME101673 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
ECD Proteins
SKU: PME101672 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
ECD Proteins
SKU: PME101671 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
ECD Proteins
SKU: PME101670 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
Overexpression Stable Cell Line
SKU: CEL100055 Target: CDH6
Application: FACS Data
Price: Inquiry
DiSliceX
SKU: SLI100004 Target: ADAM9, AFP, ALB, ANGPTL3, B7H3, CD112, CD24, CDH6, CLDN6, CLU, CXADR, GPC3, HER3, MSLN, PRLR, SCF
Application: IHC
Price: 2 slides ¥899.00
Biosimilar reference antibodies
SKU: BME100234 Target: CDH6
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Biosimilar reference antibodies
SKU: BME100232 Target: CDH6
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
ECD Proteins
SKU: PME-M100112 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
ECD Proteins
SKU: PME-C100044 Target: CDH6
Price: 10μg ¥818.00 ; 50μg ¥2999.00 ; 100 μg ¥4499.00
Monoclonal Antibodies
SKU: DMC100675 Target: CDH6
Application: Flow Cyt; WB
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
ECD Proteins
SKU: PME101111 Target: CDH6
Price: 10μg ¥727.00 ; 50μg ¥2700.00 ; 100 μg ¥3999.00
Monoclonal Antibodies
SKU: DMC100675P Target: CDH6
Application: Flow Cyt
Price: 100 test ¥3880.00
Biosimilar reference antibodies
SKU: BME100234P Target: CDH6
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100232P Target: CDH6
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100232B Target: CDH6
Application: Flow Cyt
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Monoclonal Antibodies
SKU: DMC100675B Target: CDH6
Application: Flow Cyt; WB
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00