CD73/NT5E重组蛋白抗体
CD73,又称为外-5′-核苷酸酶或5’-核苷酸酶(5’-NT),是一种由NT5E基因编码的糖基磷脂酰肌醇(GPI)锚定细胞表面蛋白。CD73 存在于多种细胞类型的表面,包括内皮细胞、淋巴细胞亚型、基质细胞和某些类型的肿瘤细胞。CD73对5′-腺苷-磷酸(5′-AMP)生成细胞外腺苷至关重要,是嘌呤信号通路的重要组成部分,该过程通过CD39的协同作用进行。
近年来,嘌呤信号通路已成为癌症进展中的重要参与者,其中细胞外ATP、ADP和腺苷作为主要信号分子。免疫抑制代谢物-腺苷是肿瘤微环境(TME)的一个组成部分。作为催化腺苷生产的主要酶,CD73主要通过产生腺苷,在抑制足够的抗肿瘤免疫反应方面至关重要,但也促进癌细胞增殖、肿瘤生长、血管生成和转移。更多CD73信号通路>>
越来越多的研究表明,CD73 是癌细胞增殖、迁移和侵袭(体外),肿瘤血管生成和肿瘤免疫逃逸(体内)的关键调控分子。基于这些作用,CD73 已成为一个有吸引力的治疗靶点。不完全统计,全球靶向CD73的药物共计89款。
为助力CD73靶向疗法开发,缔码生物现可提供HER3靶点全系列产品与服务。产品包括活性蛋白、参照抗体和流式验证单克隆抗体;服务包括多种属蛋白抗体定制服务、抗体人源化和亲和力成熟服务。此外,为加速CD73生物疗法的开发,缔码还制备了CD73靶点单B细胞种子库,最快28天可获得先导抗体分子;同时,我们目前已筛选出多个CD73先导分子,客户第二天可以拿到分子进行功能评估验证。
Overexpression Stable Cell Line
SKU: CEL100112 Target: CD73
Application: FACS Data
Price: Inquiry
Monoclonal Antibodies
SKU: DME100204B Target: CD73
Application: ELISA; Flow Cyt
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00
Biosimilar reference antibodies
SKU: BME100218 Target: CD73
Application: Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Biosimilar reference antibodies
SKU: BME100217 Target: CD73
Application: ELISA, Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
ECD Proteins
SKU: PME101511 Target: CD73
Price: 10μg ¥854.00 ; 50μg ¥3133.00 ; 100 μg ¥4699.00
ECD Proteins
SKU: PME-C100043 Target: CD73
Price: 10μg ¥818.00 ; 50μg ¥2999.00 ; 100 μg ¥4499.00
Monoclonal Antibodies
SKU: DME100204 Target: CD73
Application: ELISA; Flow Cyt
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Biosimilar reference antibodies
SKU: BME100129 Target: CD73
Application: ELISA; Flow Cyt
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
ECD Proteins
SKU: PME100829 Target: CD73
Price: 10μg ¥854.00 ; 50μg ¥3133.00 ; 100 μg ¥4699.00
Monoclonal Antibodies
SKU: DME100204P Target: CD73
Application: Flow Cyt
Price: 100 test ¥3880.00
Biosimilar reference antibodies
SKU: BME100218P Target: CD73
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100217P Target: CD73
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100129P Target: CD73
Application: Flow Cyt
Price: 100 test ¥1360.00
Biosimilar reference antibodies
SKU: BME100576B Target: CD73
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100565B Target: CD73
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100481B Target: CD73
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100413B Target: CD73
Application: N/A
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
Biosimilar reference antibodies
SKU: BME100576 Target: CD73
Application: N/A
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Biosimilar reference antibodies
SKU: BME100565 Target: CD73
Application: N/A
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00
Biosimilar reference antibodies
SKU: BME100481 Target: CD73
Application: N/A
Price: 50 μg ¥800.00 ; 100 μg ¥1500.00