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4-1BB/CD137/TNFRSF9重组蛋白与抗体
4-1BB（又称CD137、TNFRSF9）是肿瘤坏死因子受体超家族（TNFRSF）成员之一，是一种重要的免疫共刺激受体。4-1BB主要表达于活化T细胞、自然杀伤细胞（NK细胞）及部分免疫细胞表面，通过与4-1BBL结合激活下游信号通路，促进T细胞增殖、生存以及细胞毒性功能增强。作为区别于PD-1、CTLA-4等免疫抑制性检查点的免疫激活型靶点，4-1BB在增强抗肿瘤免疫反应、改善免疫细胞持续性以及推动下一代免疫治疗开发方面具有重要研究价值。因此，如何在获得充分免疫激活的同时控制非特异性刺激，是4-1BB靶向分子设计及功能评价中的重要研究方向。近年来，4-1BB被广泛应用于激动型抗体、条件性激动分子、双/多特异性抗体以及细胞治疗相关共刺激结构研究。
针对4-1BB靶点研究与抗体开发，缔码生物提供不同种属及不同胞外区域的4-1BB ECD重组蛋白、兔单克隆抗体、Biosimilar参照抗体，以及PE偶联和生物素化等多种产品形式。不同区域ECD蛋白可用于ELISA、抗体筛选、结合活性检测、表位定位及跨种属反应性评价；流式验证抗体及PE偶联抗体可用于细胞表面4-1BB表达检测和Flow Cyt分析；生物素化产品则适用于亲和素体系下的结合及筛选实验。相关产品可进一步衔接激动型抗体筛选、双抗构建和免疫细胞功能评价，为4-1BB靶向分子的早期发现和功能验证提供配套工具。
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We have various technologies for antibody-based drug development. Here is a summary of our platforms:
1. DiMProTM membrane protein platform: Use mammalian cells to express and purify membrane proteins. We have over 1000 on-shelf functional proteins, out of which, 50+ are active full-length multi-pass membrane proteins. For multi-pass transmembrane proteins, such as GPCRs and ion channels, we have five different solutions, i.e., Membrane Nanoparticle (MNP), Virus-Like Particle (VLP), Exosome (EXO), Detergent and Nanodisc.
2. DimAb® single B-cell antibody discovery platform: Our DimAb® B cell library can help customers easily obtain over 10,000 positive hits in as short as a month’s time.
3. DiLibraryTM mammalian display antibody engineering platform: A proprietary platform works great for antibody humanization, affinity maturation and other engineering applications. The developability of Ab molecules engineered from this system is much better than Abs from phage or yeast display platforms.
