| Tag | C-Flag&Strep Tag |
|---|---|
| Target | |
| Synonyms | DEE59; EIEE59; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099; NDPLHS |
| Description | Human GABR2-Strep full length protein-synthetic nanodisc |
| Delivery | In Stock |
| Uniprot ID | O75899 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Molecular Weight | The human full length GABR2-Strep protein has a MW of 105.8 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The multi-pass membrane protein belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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