Name: Human FZD1-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120242

Tag	C-Flag&Strep Tag
Target	FZD1
Synonyms	N/A
Description	Human FZD1-Strep full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	Q9UP38
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
Molecular Weight	The human full length FZD1-Strep protein has a MW of 71.2 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
Usage	Research use only
Conjugate	Unconjugated

Human FZD1-Strep full length protein-synthetic nanodisc