| Target | |
|---|---|
| Synonyms | IL12B, IL-12B, IL-12 p40, IL12 p40, IL-12 Subunit p40, Interleukin-12 Subunit Beta, Interleukin-12 Beta Chain, p40, NKSF2, NKSF, CLMF2, CLMF p40 |
| Description | Recombinant Cynomolgus IL12B protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | G7P6S2 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | IL12B(Ile23-Ser328)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 36.1 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | IL12B, also known as IL-12 p40, is a secreted glycoprotein belonging to the type I cytokine receptor family. IL12B associates with IL12A, also known as the p35 subunit, to form the heterodimeric cytokine interleukin-12 (IL-12). It can also associate with IL23A, also known as the p19 subunit, to form interleukin-23 (IL-23). IL-12 is primarily produced by activated antigen-presenting cells and promotes the activation of natural killer cells and T cells, the differentiation of T helper 1 cells, and the production of interferon-gamma. IL-23 plays an important role in the expansion and maintenance of Th17 cells and contributes to inflammatory immune responses. Dysregulation of the IL-12/IL-23 signaling pathway is associated with autoimmune and inflammatory diseases, making IL12B an important target for immunology, inflammation, and therapeutic antibody research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
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