| Target | |
|---|---|
| Synonyms | IL12B, Il12b, IL-12B, IL-12 p40, IL12 p40, IL-12p40, IL12p40, p40, Interleukin-12 Subunit Beta, Interleukin-12 Subunit p40, IL-23 Subunit p40, CLMF p40, Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit |
| Description | Recombinant mouse IL12B protein with C-terminal 10×His tag |
| Delivery | In STOCK |
| Uniprot ID | P43432 |
| Expression Host | HEK293 |
| Tag | C-10×His tag |
| Molecular Characterization | Mouse IL12B(Met23-Ser335)+10×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 37.2 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage&Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Sterility | Products are supplied non-sterile. For cell culture applications, dilute in appropriate medium and sterile-filter (0.22 µm) prior to use. |
| Background | IL12B, also known as IL-12 p40, is a secreted cytokine subunit belonging to the interleukin-12 family. IL12B associates with IL12A, also known as the p35 subunit, to form the heterodimeric cytokine IL-12. It also associates with IL23A, also known as the p19 subunit, to form IL-23. IL-12 promotes natural killer cell and T-cell activation, T helper 1 cell differentiation, and interferon-gamma production, whereas IL-23 contributes to the expansion and maintenance of Th17 cells. IL12B is mainly produced by activated antigen-presenting cells and plays important roles in host defense, inflammation, and autoimmune responses. It is an important target for immunology, inflammatory disease, and therapeutic antibody research. |
| Usage | Research use only |
| Conjugate | Unconjugated |
服务热线
400-006-0995
18062749453
